Evidence map›Paper›PMID 27710854›Full record

ArticleRedox biology2016

Albendazole as a promising molecule for tumor control.

L S E P W Castro, M R Kviecinski, F Ourique, E B Parisotto, V M A S Grinevicius, J F G Correia, D Wilhelm Filho, R C Pedrosa

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. Review
  3. Molecular and serological assessment of the therapeutic efficacy of Ivermectin Loaded nanoparticles onJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025
    Article
  4. Efficacy of nitazoxanide, ivermectin and albendazole in treatment of cryptosporidiosis in immunosuppressed mice.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025
    Article
  5. Article
  6. Drug Repurposing for Cancer Treatment: A Comprehensive Review.International journal of molecular sciences · 2024
    Review
  7. Article
  8. Article
  9. Review
  10. Exceptional Repositioning of Dog Dewormer: Fenbendazole Fever.Current issues in molecular biology · 2022
    Review
  11. Microbiology spectrum · 2022
    Article
  12. Article
  13. Double Repositioning: Veterinary Antiparasitic to Human Anticancer.International journal of molecular sciences · 2022
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

L S E P W CastroDepartment of Biochemistry, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.
M R KviecinskiPostgraduate Programe of Health Science, Universidade do Sul de Santa Catarina (UNISUL), Palhoça, SC, Brazil.
F OuriqueDepartment of Biochemistry, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.
E B ParisottoDepartment of Biochemistry, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.
V M A S GrineviciusDepartment of Biochemistry, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.
J F G CorreiaDepartment of Biochemistry, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.
D Wilhelm FilhoDepartament of Ecology and Zoology, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.
R C PedrosaDepartment of Biochemistry, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil. Electronic address: rozangelapedrosa@gmail.com.
Universidade Federal de Santa Catarina · BRUniversidade do Sul de Santa Catarina · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This work evaluated the antitumor effects of albendazole (ABZ) and its relationship with modulation of oxidative stress and induction of DNA damage. The present results showed that ABZ causes oxidative cleavage on calf-thymus DNA suggesting that this compound can break DNA. ABZ treatment decreased MCF-7 cell viability (EC

Indexed as

DNA DamageAlbendazoleAnimalsAntineoplastic AgentsCarcinoma, Ehrlich TumorCell ProliferationCell SurvivalDrug RepositioningHumansMCF-7 CellsMembrane Potential, MitochondrialMiceOxidative StressReactive Oxygen SpeciesXenograft Model Antitumor AssaysAlbendazoleAntineoplastic AgentsReactive Oxygen SpeciesAlbendazoleAntitumorApoptosisCell cycle arrestDNA fragmentationOxidative stress

Identifiers

PMID27710854
PMCPMC5053114
OpenAlexW2521851594

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.