ReviewNeuron2016
Context Processing and the Neurobiology of Post-Traumatic Stress Disorder.
Review in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 249 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
249 citing papers in PubMed, 7 syntheses or guidelines pooled it, 450 citations in OpenAlex.
- Noninvasive brain stimulation combined with evidence-based psychotherapy for psychiatric disorders: A meta-analysis of optimal implementation parameters.Neuroscience and biobehavioral reviews · 2026Pooled it
- Molecular pathways of ketamine: A systematic review of immediate and sustained effects on PTSD.Psychopharmacology · 2025Pooled it
- The nested hierarchical model of self and its non-relational vs relational posttraumatic manifestation: an fMRI meta-analysis of emotional processing.Molecular psychiatry · 2024Pooled it
- Impaired learning, memory, and extinction in posttraumatic stress disorder: translational meta-analysis of clinical and preclinical studies.Translational psychiatry · 2023Pooled it
- Extended functional connectivity of convergent structural alterations among individuals with PTSD: a neuroimaging meta-analysis.Behavioral and brain functions : BBF · 2022Pooled it
- Neural signatures of conditioning, extinction learning, and extinction recall in posttraumatic stress disorder: a meta-analysis of functional magnetic resonance imaging studies.Psychological medicine · 2020Pooled it
- Impaired hippocampus-dependent associative learning as a mechanism underlying PTSD: A meta-analysis.Neuroscience and biobehavioral reviews · 2019Pooled it
- Semantic encoding of trauma memories in the hippocampus among individuals with PTSD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- The impact of doxycycline on human contextual fear memory.Psychopharmacology · 2024Trial
- Increased top-down control of emotions during symptom provocation working memory tasks following a RCT of alpha-down neurofeedback in PTSD.NeuroImage. Clinical · 2023Trial
- Associations between resting-state functional connectivity and treatment response in a randomized clinical trial for posttraumatic stress disorder.Depression and anxiety · 2020Trial
- A randomized, controlled trial of alpha-rhythm EEG neurofeedback in posttraumatic stress disorder: A preliminary investigation showing evidence of decreased PTSD symptoms and restored default mode and salience network connectivity using fMRI.NeuroImage. Clinical · 2020Trial
- Using fMRI connectivity to define a treatment-resistant form of post-traumatic stress disorder.Science translational medicine · 2019Trial
- Associations Among Hair Cortisol Concentrations, Posttraumatic Stress Disorder Status, and Amygdala Reactivity to Negative Affective Stimuli in Female Police Officers.Journal of traumatic stress · 2019Trial
- Post-traumatic stress disorder: pathogenesis, epidemiological characteristics, animal models, and potential therapeutic strategies.Military Medical Research · 2026Review
- CRH neurons in the dorsal bed nucleus of the stria terminalis (dBNST) mediate contextual fear generalization.Neurobiology of stress · 2026Article
- Context processing as a moderator of the association between posttraumatic stress symptoms and the adaptation of maternal sensitivity following stress related to separation.Infant mental health journal · 2026Article
- Re-experiencing trauma: Occipital lobe resting-state functional connectivity in posttraumatic stress disorder.Psychiatry research. Neuroimaging · 2026Article
- Prior trauma shapes the effects of psilocybin on stress sensitization in mice.Neuroscience letters · 2026Article
- Altered Scale-Free Dynamics of Spontaneous Brain Activity in Post-Traumatic Stress Disorder: Relationship to Impaired Functional Connectivity.Brain sciences · 2026Article
189 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Progress in clinical and affective neuroscience is redefining psychiatric illness as symptomatic expression of cellular/molecular dysfunctions in specific brain circuits. Post-traumatic stress disorder (PTSD) has been an exemplar of this progress, with improved understanding of neurobiological systems subserving fear learning, salience detection, and emotion regulation explaining much of its phenomenology and neurobiology. However, many features remain unexplained and a parsimonious model that more fully accounts for symptoms and the core neurobiology remains elusive. Contextual processing is a key modulatory function of hippocampal-prefrontal-thalamic circuitry, allowing organisms to disambiguate cues and derive situation-specific meaning from the world. We propose that dysregulation within this context-processing circuit is at the core of PTSD pathophysiology, accounting for much of its phenomenology and most of its biological findings. Understanding core mechanisms like this, and their underlying neural circuits, will sharpen diagnostic precision and understanding of risk factors, enhancing our ability to develop preventive and "personalized" interventions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.