Evidence map›Paper›PMID 27709809›Full record

ArticleAdvanced healthcare materials2016

Regulating Stem Cell Secretome Using Injectable Hydrogels with In Situ Network Formation.

Lei Cai, Ruby E Dewi, Andrew B Goldstone, Jeffrey E Cohen, Amanda N Steele, Y Joseph Woo, Sarah C Heilshorn

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Stem Cell's Secretome Delivery Systems.Advanced pharmaceutical bulletin · 2023
    Review
  10. New treatment methods for myocardial infarction.Frontiers in cardiovascular medicine · 2023
    Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Alginate-International journal of molecular sciences · 2021
    Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lei CaiDepartment of Materials Science and Engineering, Stanford Neuroscience Institute, Stanford University, Stanford, CA, 94305, USA.
Ruby E DewiDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, 94305, USA.
Andrew B GoldstoneDepartment of Cardiothoracic Surgery, Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA.
Jeffrey E CohenDepartment of Cardiothoracic Surgery, Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA.
Amanda N SteeleDepartment of Cardiothoracic Surgery, Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA.
Y Joseph WooDepartment of Cardiothoracic Surgery, Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA.
Sarah C HeilshornDepartment of Materials Science and Engineering, Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA.

Funding

Injectable Hydrogels to Improve the Efficacy of iPSC-derived TherapiesR21EB020235 · NIBIB · STANFORD UNIVERSITY · PI HEILSHORN, SARAH C, HUANG, NGAN F. · 2015 to 2016
$433k
Design of injectable hydrogels to improve cell transplantation for peripheral arterial diseaseF32HL128094 · NHLBI · STANFORD UNIVERSITY · PI CAI, LEI · 2015 to 2016
$64k
NHLBI NIH HHS F32 HL128094NIBIB NIH HHS R21 EB020235
6 · The paper itself

Abstract

A family of shear-thinning hydrogels for injectable encapsulation and long-term delivery (SHIELD) has been designed and synthesized with controlled in situ stiffening properties to regulate the stem cell secretome. The authors demonstrate that SHIELD with an intermediate stiffness (200-400 Pa) could significantly promote the angiogenic potential of human adipose-derived stem cells.

Indexed as

Adipose TissueCells, CulturedHumansHydrogelsInjectionsIntercellular Signaling Peptides and ProteinsRheologyStem CellsHydrogelsIntercellular Signaling Peptides and Proteinsangiogenic functioninjectable hydrogelsmolecular recognitionreinforcing networkstem cell secretome

Identifiers

PMID27709809
PMCPMC5521188

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.