Evidence map›Paper›PMID 27709757›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2017

Increased basal ganglia binding of

Ruben Smith, Martin Schain, Christer Nilsson, Olof Strandberg, Tomas Olsson, Douglas Hägerström, Jonas Jögi, Edilio Borroni, Michael Schöll, Michael Honer and 1 more

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01208675 (The Swedish BioFINDER Study), which is not on this map. Cited by 76 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01208675 completednot on this map

The Swedish BioFINDER Study: Early Diagnosis of Alzheimer's Disease - a Multidisciplinary Approach

TypeobservationalSponsorSkane University HospitalRan2010 to 2024Enrolled1,150ConditionsMild Cognitive Impairment, Alzheimer's Disease, Dementia With Lewy Bodies, Vascular Dementia
3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.

  1. Pooled it
  2. Evaluation of [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Trial
  3. Article
  4. Asymmetry in Atypical Parkinsonian Syndromes-A Review.Journal of clinical medicine · 2024
    Review
  5. Review
  6. Direct comparison betweenNeuroImage · 2024
    Article
  7. Review
  8. A novelFrontiers in neurology · 2024
    Article
  9. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  10. Review
  11. Article
  12. Review
  13. The tauopathies: Neuroimaging characteristics and emerging experimental therapies.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022
    Review
  14. Article
  15. Direct Comparison of the Tau PET TracersJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  16. Review
  17. [Neurology · 2021
    Article
  18. Review
  19. Neuroinflammation predicts disease progression in progressive supranuclear palsy.Journal of neurology, neurosurgery, and psychiatry · 2021
    Article
  20. Review

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Ruben SmithSkåne University Hospital, Department of Neurology, Lund, Sweden.
Martin SchainLund University, Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Malmö, Sweden.
Christer NilssonSkåne University Hospital, Department of Neurology, Lund, Sweden.
Olof StrandbergLund University, Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Malmö, Sweden.
Tomas OlssonSkåne University Hospital, Department of Radiation Physics, Lund, Sweden.
Douglas HägerströmSkåne University Hospital, Department of Clinical Neurophysiology, Lund, Sweden.
Jonas JögiSkåne University Hospital, Department of Clinical Physiology and Nuclear Medicine, Lund, Sweden.
Edilio BorroniRoche Pharmaceutical Research and Early Development, Neuroscience Discovery & Biomarkers, Roche Innovation Center, Basel, Switzerland.
Michael SchöllLund University, Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Malmö, Sweden.
Michael HonerRoche Pharmaceutical Research and Early Development, Neuroscience Discovery & Biomarkers, Roche Innovation Center, Basel, Switzerland.
Oskar HanssonLund University, Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Malmö, Sweden.
Skåne University Hospital · SELund University · SERoche (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProgressive supranuclear palsy (PSP) is difficult to diagnose accurately. The recently developed tau PET tracers may improve the diagnostic work-up of PSP.

methodsRegional tau accumulation was studied using

results

conclusionWe found higher

Indexed as

CarbolinesAgedAge FactorsBasal GangliaCerebral CortexHumansPositron-Emission TomographySupranuclear Palsy, ProgressiveSwedentau Proteins7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indoleCarbolinestau Proteinsbasal gangliapositron emission tomographyProgressive supranuclear palsytau

Identifiers

PMID27709757
PMCPMC6204612
OpenAlexW2527707692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.