ArticleClinical and translational medicine2016
Adult pulmonary tuberculosis as a pathological manifestation of hyperactive antimycobacterial immune response.
Article in Clinical and translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The impact of cytomegalovirus coinfection on tuberculosis in the mouse model.BMC infectious diseases · 2026Article
- The tuberculosis-associated microenvironment promotes HIV-1 persistence by impairing CD8+ T cell-mediated viral control.bioRxiv : the preprint server for biology · 2025Article
- Effect of exposure to ambient particulate matter on risk of developing pulmonary tuberculosis: A systematic review and meta-analysis.Lung India : official organ of Indian Chest Society · 2025Article
- Ambient PMEpidemiology and infection · 2025Article
- Analysis of Lymphocyte Immunologic Indexes in the Early Diagnosis of Active Pulmonary Tuberculosis of Adolescents in China.Infection and drug resistance · 2025Article
- Article
- Myeloid cell expression of CD200R is modulated in active TB disease and regulatesFrontiers in immunology · 2024Article
- Iron Status and Supplementation during Tuberculosis.Microorganisms · 2023Review
- Article
- Article
- Oxidative Stress and Inflammatory Mediators in Exhaled Breath Condensate of Patients with Pulmonary Tuberculosis. A Pilot Study with a Biomarker Perspective.Antioxidants (Basel, Switzerland) · 2021Article
- A Perspective on the Success and Failure of BCG.Frontiers in immunology · 2021Article
- The Manipulation of the Lipid Mediator Metabolism as Adjunct Host-Directed Therapy in Tuberculosis.Frontiers in immunology · 2021Review
- Antiretroviral Treatment Failure and Associated Factors Among HIV-Infected Children on Antiretroviral Therapy: A Retrospective Study.HIV/AIDS (Auckland, N.Z.) · 2021Article
- The Pathogenesis of Tuberculosis-The Koch Phenomenon Reinstated.Pathogens (Basel, Switzerland) · 2020Review
- Elevated Levels of Galectin-9 but Not Osteopontin in HIV and Tuberculosis Infections Indicate Their Roles in Detecting MTB Infection in HIV Infected Individuals.Frontiers in microbiology · 2020Article
- Impact of the Polymorphism of theIranian journal of medical sciences · 2019Article
- Sex differences in tuberculosis.Seminars in immunopathology · 2019Review
- CCR4-dependent reduction in the number and suppressor function of CD4Cell death & disease · 2018Article
- The Pathogenesis of Tuberculosis: The Early Infiltrate of Post-primary (Adult Pulmonary) Tuberculosis: A Distinct Disease Entity.Frontiers in immunology · 2018Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intricate relationship between tuberculosis (TB) and immune system remains poorly understood. It is generally believed that weakening of the immune response against Mycobacterium tuberculosis leads to reactivation of latent infection into the active pulmonary disease. However, heterogeneous nature of TB and failure of rationally designed vaccines in clinical trials raises serious questions against the simplistic view of TB as an outcome of weakened immunity. In the wake of accumulating human TB data, it is argued here that a hyperactive antimycobacterial immune response is to blame for the pathogenesis of pulmonary TB in immunocompetent adults. Direct and indirect evidence supporting this notion is presented in this article. Revisiting the role of immune system in TB pathogenesis will pave the way for effective anti-TB vaccines.
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