ReviewCurrent infectious disease reports2016
Understanding Long-Term Outcomes Following Sepsis: Implications and Challenges.
Review in Current infectious disease reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03133208 (Serum Biomarkers in Sepsis Associated Encephalopathy), which is not on this map. Cited by 108 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Serum Biomarkers in Sepsis Associated Encephalopathy (SAE)
Who cites it
108 citing papers in PubMed, 4 syntheses or guidelines pooled it, 192 citations in OpenAlex.
- Healthcare costs after sepsis: a systematic review.Critical care (London, England) · 2025Pooled it
- Rapid systematic review on risks and outcomes of sepsis: the influence of risk factors associated with health inequalities.International journal for equity in health · 2024Pooled it
- Association between sepsis survivorship and long-term cardiovascular outcomes in adults: a systematic review and meta-analysis.Intensive care medicine · 2021Pooled it
- Rate and risk factors for rehospitalisation in sepsis survivors: systematic review and meta-analysis.Intensive care medicine · 2020Pooled it
- Trajectories of sepsis survivors in Australia: A scoping review.Journal of the Intensive Care Society · 2026Article
- Secretory LGALS3BP exacerbates sepsis-associated liver dysfunction by activating inflammasome-mediated pyroptosis.Cell death discovery · 2026Article
- Renal dysfunction as a marker of adverse outcomes in early sepsis in the emergency department.Clinical and experimental emergency medicine · 2026Article
- Precision medicine in sepsis: lessons from the TIGRIS trial and the reawakening of targeted therapy.Journal of anesthesia, analgesia and critical care · 2026Review
- Sepsis policy, guidelines, and standards in Canada: a jurisdictional scoping review.BMC health services research · 2026Article
- Machine Learning Models for Sepsis: From Early Detection to Short- and Long-Term Prognosis.International journal of molecular sciences · 2026Article
- Optimizing sepsis mortality prediction using hybrid federated learning and explainable AI framework.Scientific reports · 2026Article
- Effects of the glucagon-like peptide-1 receptor agonist liraglutide on retinal endothelial function and oxidative stress during sepsis.Frontiers in pharmacology · 2026Article
- Demographic and regional trends in pneumonia and sepsis related mortality in the U.S., 1999-2020: a CDC wonder database analysis.Frontiers in public health · 2026Article
- Association between the use of β-adrenergic receptor blockers and all-cause mortality in sepsis-associated rhabdomyolysis syndrome: a cohort study.Frontiers in medicine · 2026Article
- Global Assessment of Health Utilities Associated with Pneumococcal Disease in Adults: Targeted Literature Reviews.PharmacoEconomics - open · 2026Review
- Endothelial cells retain inflammatory memory through chromatin remodeling in a two-hit model of infection-induced inflammation.American journal of physiology. Cell physiology · 2025Article
- Disease trajectory and mortality among sepsis patients: a prospective cohort study.BMC infectious diseases · 2025Article
- Raman Spectroscopy Can Identify Acute and Persistent Biochemical Changes in Leukocytes From Patients With COVID-19 and Non-COVID-19-Associated Sepsis.Biotechnology journal · 2025Article
- Sepsis criteria and kidney function: eliminating sex, age and economic status biases.Nature reviews. Nephrology · 2025Review
- Dysregulated neural coding in the vagus nerve during long sepsis.Brain, behavior, & immunity - health · 2025Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is life-threating organ dysfunction due to infection. Incidence of sepsis is increasing and the short-term mortality is improving, generating more sepsis survivors. These sepsis survivors suffer from additional morbidities such as higher risk of readmissions, cardiovascular disease, cognitive impairment and of death, for years following index sepsis episode. In the first year following index sepsis episode, approximately 60 % of sepsis survivors have at least one rehospitalisation episode, which is most often due to infection and one in six sepsis survivors die. Sepsis survivors also have a higher risk of cognitive impairment and cardiovascular disease contributing to the reduced life expectancy seen in this population, when assessed with life table comparisons. For optimal design of interventional trials to reduce these bad outcomes in sepsis survivors, in-depth understanding of major risk factors for these morbid events, their modifiability and a causal relationship to the pathobiology of sepsis is essential. This review highlights the recent advances, clinical and methodological challenges in our understanding of these morbid events in sepsis survivors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.