Evidence map›Paper›PMID 27709457›Full record

ArticleCerebellum (London, England)2017

Defining Trends in Global Gene Expression in Arabian Horses with Cerebellar Abiotrophy.

E Y Scott, M C T Penedo, J D Murray, C J Finno

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebellum (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Cerebellar Abiotrophy Across Domestic Species.Cerebellum (London, England) · 2018
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

E Y ScottDepartment of Animal Science, University of California, Davis, USA.
M C T PenedoVeterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, USA.
J D MurrayDepartment of Animal Science, University of California, Davis, USA. JDMurray@ucdavis.edu.
C J FinnoDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, USA. cjfinno@ucdavis.edu.
University of California, Davis · US

Funding

Molecular pathogenesis of alpha-tocopherol associated neuroaxonal dystrophy in anK01OD015134 · OD · UNIVERSITY OF MINNESOTA · PI FINNO, CARRIE · 2013 to 2017
$599k
NCATS NIH HHS L40 TR001136NIH HHS K01 OD015134
6 · The paper itself

Abstract

Equine cerebellar abiotrophy (CA) is a hereditary neurodegenerative disease that affects the Purkinje neurons of the cerebellum and causes ataxia in Arabian foals. Signs of CA are typically first recognized either at birth to any time up to 6 months of age. CA is inherited as an autosomal recessive trait and is associated with a single nucleotide polymorphism (SNP) on equine chromosome 2 (13074277G>A), located in the fourth exon of TOE1 and in proximity to MUTYH on the antisense strand. We hypothesize that unraveling the functional consequences of the CA SNP using RNA-seq will elucidate the molecular pathways underlying the CA phenotype. RNA-seq (100 bp PE strand-specific) was performed in cerebellar tissue from four CA-affected and five age-matched unaffected horses. Three pipelines for differential gene expression (DE) analysis were used (Tophat2/Cuffdiff2, Kallisto/EdgeR, and Kallisto/Sleuth) with 151 significant DE genes identified by all three pipelines in CA-affected horses. TOE1 (Log

Indexed as

TranscriptomeAnimalsCerebellumCluster AnalysisDNA GlycosylasesFemaleGene ExpressionHeredodegenerative Disorders, Nervous SystemHorse DiseasesHorsesMalePolymerase Chain ReactionPolymorphism, Single NucleotideUnsupervised Machine LearningDNA GlycosylasesmutY adenine glycosylaseCalciumCerebellar abiotrophyHorseMicroglial activationRNA-seq

Identifiers

PMID27709457
PMCPMC5336519
OpenAlexW2528767491

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.