Evidence map›Paper›PMID 27709450›Full record

ArticleInternational journal of hematology2016

Analysis of allogeneic hematopoietic stem cell transplantation with high-dose cyclophosphamide-induced immune tolerance for severe aplastic anemia.

Zhi Guo, Hong-Yan Gao, Tian-Yan Zhang, Xiao-Dong Liu, Kai Yang, Jing-Xing Lou, Xue-Peng He, Yuan Zhang, Peng Chen, Hui-Ren Chen

Abstract read
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Article in International journal of hematology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Zhi GuoDepartment of Hematology, PLA Army General Hospital, Beijing, 100700, China.
Hong-Yan GaoDepartment of Hematology, PLA Army General Hospital, Beijing, 100700, China.
Tian-Yan ZhangDepartment of Hematology, PLA Army General Hospital, Beijing, 100700, China.
Xiao-Dong LiuDepartment of Hematology, PLA Army General Hospital, Beijing, 100700, China.
Kai YangDepartment of Hematology, PLA Army General Hospital, Beijing, 100700, China.
Jing-Xing LouDepartment of Hematology, PLA Army General Hospital, Beijing, 100700, China.
Xue-Peng HeDepartment of Hematology, PLA Army General Hospital, Beijing, 100700, China.
Yuan ZhangDepartment of Hematology, PLA Army General Hospital, Beijing, 100700, China.
Peng ChenDepartment of Hematology, PLA Army General Hospital, Beijing, 100700, China.
Hui-Ren ChenDepartment of Hematology, PLA Army General Hospital, Beijing, 100700, China. donnydada@163.com.
The Military General Hospital of Beijing PLA · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study was aimed to explore the efficacy and safety of allo-HSCT with high-dose cyclophosphamide-induced immune tolerance for SAA. In the present study, 20 cases (12 male, 8 female; average age = 17.8 years) received reduced-intensity conditioning allo-HSCT from August 2012 to August 2014 in the Beijing Military Region General Hospital. All were HLA mismatched and received CSA; 11 received ATG-intensive immune therapy. Donors underwent mobilization with cell colony-stimulating factor. The modified preconditioning regimen included reduced-strength fludarabine combined with Busulfex and cytarabine, cyclophosphamide. Cyclophosphamide (50 mg/kg/d) induced immune tolerance 3 days after transplantation and was combined with immunosuppressive agents, including CSA, MTX, and FK506, for GVHD prophylaxis and the management of observed toxicity, GVHD and DFS. Hematopoietic reconstitution was achieved in 17 cases and engraftment after a second transplantation in an additional three cases. The average times to engraftment were 17.4 and 21.3 days, respectively, with neutrophils ≥0.5 × 10

Indexed as

AdolescentAdultAnemia, AplasticChildCyclophosphamideDisease-Free SurvivalFemaleGraft vs Host DiseaseHematopoietic Stem Cell MobilizationHematopoietic Stem Cell TransplantationHumansImmune ToleranceImmunosuppressive AgentsMaleTransplantation ConditioningTransplantation, HomologousCyclophosphamideImmunosuppressive AgentsAllogeneic hematopoietic stem cell transplantationCyclophosphamideDisease-free survivalImmune tolerancePretreatmentSevere aplastic anemia

Identifiers

PMID27709450
OpenAlexW2529570749

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.