ArticleHead and neck pathology2017
S-100 Negative Granular Cell Tumor (So-called Primitive Polypoid Non-neural Granular Cell Tumor) of the Oral Cavity.
Article in Head and neck pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Cutaneous granular cell tumor presenting as a solitary preauricular nodule: a case report.Frontiers in medicine · 2025Article
- Oral Granular Cell Tumour on the Mandibular Gingiva in an Adult: A Rare Case Report.Case reports in dentistry · 2025Article
- Malignant granular cell tumour of floor of mouth (non-neural in origin) - A rare case report and review of literature.SAGE open medical case reports · 2024Article
- Lip Granular Cell Tumor (GCT) in a Pediatric Patient: Critical Literature Review on Pediatric Intraoral GCT and Acquired and Congenital Intraoral Non-Neural GCT.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Clinical and pathological analysis of congenital granular cell tumor.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2022Article
- Granular cell dermatofibroma: A potential diagnostic pitfall.Dermatology reports · 2022Article
- Granular Cell Dermatofibroma: When Morphology Still Matters.Dermatopathology (Basel, Switzerland) · 2021Article
- Congenital Granular Cell Epulis: Classic Presentation and Its Differential Diagnosis.Head and neck pathology · 2020Article
- A rare case of a non-neural granular cell tumor presenting as an enlarging right chest wall nodule in a 4-year-old male and review of the literature.SAGE open medical case reports · 2020Article
- S-100-Negative malignant pulmonary granular cell tumor: A case report.Respiratory medicine case reports · 2020Article
- Oral neural tumors: Clinicopathologic analysis of 157 cases and review of the literature.Journal of clinical and experimental dentistry · 2019Article
- A Guide to Yellow Oral Mucosal Entities: Etiology and Pathology.Head and neck pathology · 2019Review
- S100 negative granular cell tumor of the oral cavity: dermoscopy and surgical approach.Anais brasileiros de dermatologiaArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Four cases of cutaneous S-100 negative granular cell tumor were described in 1991. Until now, only 3 cases of oral involvement have been documented in English literature. Two additional cases of oral S-100 negative granular cell tumor are described. Immunohistochemical markers were applied to exclude other lesions that may show the presence of granular cells. The clinical findings were correlated with the histopathological and immunohistochemical features to arrive at the appropriate diagnosis. S-100 negative granular cell tumors are erythematous polypoid masses commonly mistaken for granulation tissue or a pyogenic granuloma. Any part of the oral cavity may be affected. Histopathologically, the lesions consist of sheets, nests, and fascicles of granular cells that are S-100 negative. The granular cells are non-reactive to SMA, HMB45, Melan A, and CD163. The intracytoplasmic granules are diffusely and strongly positive to NKI/C3. The cell lineage of the S-100 negative granular cell tumor is obscure. Absence of staining with CD163 excludes a histiocytic lineage. Absence of staining with S-100 excludes a neural origin. Absence of staining with S-100 and key melanoma markers HMB45 and Melan A also excludes a melanocytic origin. In this context, positive reactivity with NKI/C3 is indicative of presence of intracytoplasmic lysosomal granules only. Greater awareness of this lesion in the oral cavity will result in better characterization of its biologic potential.
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