Evidence map›Paper›PMID 27709413›Full record

ReviewCurrent rheumatology reports2016

Immune Cell Metabolism in Systemic Lupus Erythematosus.

Seung-Chul Choi, Anton A Titov, Ramya Sivakumar, Wei Li, Laurence Morel

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current rheumatology reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Cellular Metabolic Disorders in a Cohort of Patients with Sjogren's Disease.International journal of molecular sciences · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Epitranscriptomic N4-Acetylcytidine Profiling in CD4Frontiers in cell and developmental biology · 2020
    Article
  10. Article
  11. Review
  12. Immune cell metabolism in autoimmunity.Clinical and experimental immunology · 2019
    Review
  13. Metabolic abnormalities and oxidative stress in lupus.Current opinion in rheumatology · 2017
    Review
  14. T cells and autoimmune kidney disease.Nature reviews. Nephrology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Seung-Chul ChoiDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, 32610-0275, USA.
Anton A TitovDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, 32610-0275, USA.
Ramya SivakumarDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, 32610-0275, USA.
Wei LiDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, 32610-0275, USA.
Laurence MorelDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, 32610-0275, USA. morel@ufl.edu.

Funding

Targeting follicular helper CD4 T cells in SLER01AI128901 · NIAID · UNIVERSITY OF FLORIDA · PI MOREL, LAURENCE · 2017 to 2021
$1.8M
NIAID NIH HHS R01 AI128901
6 · The paper itself

Abstract

Cellular metabolism represents a newly identified checkpoint of effector functions in the immune system. A solid body of work has characterized the metabolic requirements of normal T cells during activation and differentiation into polarized effector subsets. Similar studies have been initiated to characterize the metabolic requirements for B cells and myeloid cells. Only a few studies though have characterized the metabolism of immune cells in the context of autoimmune diseases. Here, we review what is known on the altered metabolic patterns of CD4

Indexed as

AutoimmunityB-LymphocytesHumansLupus Erythematosus, SystemicT-LymphocytesAutoimmunityB cellsImmunometabolismLupusMyeloid cellsT cellsTherapeutic targets

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.