SynthesisNeurosurgical review2018
Radiation-induced gliomas: a comprehensive review and meta-analysis.
Synthesis in Neurosurgical review, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 85 citations in OpenAlex.
- Development of high-grade glioma as a second malignant neoplasm in patients treated for primary brain tumors.Discover oncology · 2026Article
- Incidence of rare malignant transformation in vestibular schwannomas treated with stereotactic radiosurgery: a single-institution analysis of 1,061 cases.Journal of neuro-oncology · 2025Article
- Malignant transformation of pituitary adenoma to carcinosarcoma: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Two pediatric patients with secondary glioblastoma following radiotherapy for acute lymphoblastic leukemia: a case report.World journal of surgical oncology · 2025Article
- Proton beam therapy in a patient with secondary glioblastoma (32 years after postoperative irradiation of medulloblastoma): case report and literature review.Radiation oncology (London, England) · 2024Review
- Imaging-tracked progression of primary leptomeningeal gliomatosis: A case report.Surgical neurology international · 2024Article
- Radiation-Induced Low-Grade Glioma following Radiotherapy for Squamous Cell Carcinoma of the Scalp: Case Report and Literature Review.Case reports in surgery · 2024Article
- Mitigating Radiotoxicity in the Central Nervous System: Role of Proton Therapy.Current treatment options in oncology · 2023Review
- Advances in Glioblastoma Therapy: An Update on Current Approaches.Brain sciences · 2023Review
- Mapping pediatric brain tumors to their origins in the developing cerebellum.Neuro-oncology · 2023Article
- Epithelioid glioblastoma diagnosed 70 years after craniofacial radiotherapy.Acta neurochirurgica · 2023Article
- Clinical and genomic features in patients with second primary glioblastoma following first primary renal cell carcinoma.BMC cancer · 2023Article
- Investigation of incidence and geographic distribution of gliomas in Canada from 1992 to 2010: a national population-based study highlighting the importance of exposure to airport operations.Frontiers in oncology · 2023Article
- FAM72A promotes glioma progression by regulating mitophagy through the Pink1/Parkin signaling pathway.Journal of Cancer · 2023Article
- Allyl Isothiocyanate (AITC) Induces Apoptotic Cell Death In Vitro and Exhibits Anti-Tumor Activity in a Human Glioblastoma GBM8401/International journal of molecular sciences · 2022Article
- Characteristics and therapeutic strategies of radiation-induced glioma: case series and comprehensive literature review.Journal of neuro-oncology · 2022Review
- Nanotechnology-Based Combinatorial Anti-Glioblastoma Therapies: Moving from Terminal to Treatable.Pharmaceutics · 2022Review
- Assessment of therapeutic outcome and role of reirradiation in patients with radiation-induced glioma.Radiation oncology (London, England) · 2022Article
- Synchronous glioblastoma and brain metastases: illustrative case.Journal of neurosurgery. Case lessons · 2022Article
- Bisdemethoxycurcumin Induces Cell Apoptosis and Inhibits Human Brain Glioblastoma GBM 8401/International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By conducting a systemic search of the PubMed database, we performed a comprehensive literature review to characterize secondary gliomas following radiotherapy treatment and to determine the most appropriate treatment strategy. Our analysis included 296 cases of radiation-induced gliomas. The primary lesion was characterized as a hematological malignancy in 104 cases (35.1 %), pituitary adenoma in 35 (11.8 %), craniopharyngioma in 19 (6.4 %), medulloblastoma in 38 (12.8 %), germ cell tumor in 13 (4.3 %), low-grade glioma in 28 (9.4 %), cancer/sarcoma in 12 (4.0 %), scalp region disease in 15 (5.0 %), meningioma/schwannoma in 13 (4.3 %), metastatic brain tumor in 5 (1.6 %), and other types (e.g., arteriovenous malformations and angiomas) in 14 (4.7 %). The average age of onset for primary lesions was 16.0 ± 15.8 years, and the average radiation dose delivered to the primary lesion was 37.6 ± 20.0 Gy. Secondary gliomas could be divided into grade I (1), grade II (32), grade III (88), and grade IV (173) tumors. The median overall survival for all glioma cases was 11 months (95 % confidence interval [CI], 9-12), with a 2-year survival rate of 20.2 %. On multivariate analysis, combined modality treatment and the latency period from the radiotherapy treatment to the glioma diagnosis were variables associated with the overall survival of patients with grade III/IV secondary gliomas. For patients treated with cranial radiotherapy, the risk of secondary glioma incidence warrants a longer follow-up period beyond the standard time frame typically designated for determining the risk of primary tumor relapse. Moreover, combination therapy is a potential treatment option for radiation-induced gliomas.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.