Trial reportEuropean radiology2017
High rates of clinically relevant incidental findings by total-body CT scanning in trauma patients; results of the REACT-2 trial.
Trial report in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Pooled it
- Diagnostic utility of whole-body computed tomography/pan-scan in trauma: a systematic review and meta-analysis study.Emergency radiology · 2024Pooled it
- Clinical significance of incidental findings on coronary CT angiography: Insights from a randomized controlled trial.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Trial
- Refining the criteria for immediate total-body CT after severe trauma.European radiology · 2020Trial
- Development of a deep learning model for detecting and measuring gallstones on computed tomography images.Abdominal radiology (New York) · 2026Article
- Automated detection of gallbladder stones using a deep learning algorithm on computed tomography scans.Abdominal radiology (New York) · 2026Article
- Time trend analysis of Injury Severity score of adult trauma patients with emergent CT examination.Emergency radiology · 2024Article
- The clinical implications of using a low threshold for computed tomography scans in older patients presenting with a proximal femur fracture.European geriatric medicine · 2024Article
- GBA/GBN-position on the feedback of incidental findings in biobank-based research: consensus-based workflow for hospital-based biobanks.European journal of human genetics : EJHG · 2023Article
- Implementing a Streamlined Radiology Workflow to Close the Loop on Incidental Imaging Findings in the Emergency Department.Journal of digital imaging · 2023Article
- Diagnosis of cancer in the Emergency Department: A scoping review.Cancer medicine · 2023Article
- Ascending Aortic Aneurysms <4.5 cm for Nonsyndromic Adults: Very Slow Growth and Low Risk.Aorta (Stamford, Conn.) · 2023Article
- Incidental Findings on Computerized Tomography Images of Trauma Cases.Archives of Iranian medicine · 2022Article
- Incidental CT Findings in the Elderly with Low-Energy Falls: Prevalence and Implications.Diagnostics (Basel, Switzerland) · 2022Article
- European Society of Emergency Radiology: guideline on radiological polytrauma imaging and service (short version).Insights into imaging · 2020Article
- [Update polytrauma and computed tomography in ongoing resuscitation : ABCDE and "diagnose first what kills first"].Der Radiologe · 2020Review
- Whole Body CT Imaging in Deceased Donor Screening for Malignancies.Transplantation direct · 2019Article
- Incidental findings in thoracic CTs performed in trauma patients: an underestimated problem.European radiology · 2019Article
- Incidental findings on whole-body computed tomography in trauma patients: the current state of incidental findings and the effect of implementation of a feedback system.Acute medicine & surgery · 2019Article
- [Relevant incidental findings and iatrogenic injuries : A retrospective analysis of 1165 resuscitation room patients].Der Anaesthesist · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine whether there is a difference in frequency and clinical relevance of incidental findings detected by total-body computed tomography scanning (TBCT) compared to those by the standard work-up (STWU) with selective computed tomography (CT) scanning.
methodsTrauma patients from five trauma centres were randomized between April 2011 and January 2014 to TBCT imaging or STWU consisting of conventional imaging with selective CT scanning. Incidental findings were divided into three categories: 1) major finding, may cause mortality; 2) moderate finding, may cause morbidity; and 3) minor finding, hardly relevant. Generalized estimating equations were applied to assess differences in incidental findings.
resultsIn total, 1083 patients were enrolled, of which 541 patients (49.9 %) were randomized for TBCT and 542 patients (50.1 %) for STWU. Major findings were detected in 23 patients (4.3 %) in the TBCT group compared to 9 patients (1.7 %) in the STWU group (adjusted rate ratio 2.851; 95%CI 1.337-6.077; p < 0.007). Findings of moderate relevance were detected in 120 patients (22.2 %) in the TBCT group compared to 86 patients (15.9 %) in the STWU group (adjusted rate ratio 1.421; 95%CI 1.088-1.854; p < 0.010).
conclusionsCompared to selective CT scanning, more patients with clinically relevant incidental findings can be expected by TBCT scanning. KEY POINTS: • Total-body CT scanning in trauma results in 1.5 times more incidental findings. • Evaluation by TBCT in trauma results in more patients with incidental findings. • In every category of clinical relevance, TBCT detects more incidental findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.