Evidence map›Paper›PMID 27709268›Full record

ArticleExperimental brain research2017

The neuronal metabolite NAA regulates histone H3 methylation in oligodendrocytes and myelin lipid composition.

N K Singhal, H Huang, S Li, R Clements, J Gadd, A Daniels, E E Kooijman, P Bannerman, T Burns, F Guo and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. The Emerging Role of N-Acetylaspartate in Cancer.International journal of molecular sciences · 2026
    Review
  5. Article
  6. Cell-specific isotope labeling identifiesbioRxiv : the preprint server for biology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

N K SinghalDepartment of Biological Sciences and School of Biomedical Sciences, Kent State University, Kent, OH, 44242, USA.
H HuangDepartment of Chemistry and Biology, University of Akron, Akron, OH, 44325, USA.
S LiDepartment of Biological Sciences and School of Biomedical Sciences, Kent State University, Kent, OH, 44242, USA.
R ClementsDepartment of Biological Sciences and School of Biomedical Sciences, Kent State University, Kent, OH, 44242, USA.
J GaddDepartment of Biological Sciences and School of Biomedical Sciences, Kent State University, Kent, OH, 44242, USA.
A DanielsDepartment of Biological Sciences and School of Biomedical Sciences, Kent State University, Kent, OH, 44242, USA.
E E KooijmanDepartment of Biological Sciences and School of Biomedical Sciences, Kent State University, Kent, OH, 44242, USA.
P BannermanDepartment of Cell Biology and Human Anatomy, UC Davis School of Medicine, Sacramento, CA, 95817, USA.
T BurnsDepartment of Neurology, UC Davis School of Medicine, Sacramento, CA, 95817, USA.
F GuoDepartment of Neurology, UC Davis School of Medicine, Sacramento, CA, 95817, USA.
D PleasureDepartment of Neurology, UC Davis School of Medicine, Sacramento, CA, 95817, USA.
E FreemanDepartment of Biological Sciences and School of Biomedical Sciences, Kent State University, Kent, OH, 44242, USA.
L ShriverDepartment of Chemistry and Biology, University of Akron, Akron, OH, 44325, USA.
J McDonoughDepartment of Biological Sciences and School of Biomedical Sciences, Kent State University, Kent, OH, 44242, USA. jmcdonou@kent.edu.
Kent State University · USUniversity of California, Davis · USUniversity of Akron · US

Funding

The Wnt-independent role of TCF7l2 in CNS myelin formation and repairR01NS094559 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GUO, FUZHENG · 2016 to 2020
$1.4M
The curious case of Wnt effector TCF712 in CNS myelination and remyelinationR21NS093559 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GUO, FUZHENG · 2016 to 2016
$235k
NINDS NIH HHS R01 NS094559NINDS NIH HHS R21 NS093559
6 · The paper itself

Abstract

The neuronal mitochondrial metabolite N-acetylaspartate (NAA) is decreased in the multiple sclerosis (MS) brain. NAA is synthesized in neurons by the enzyme N-acetyltransferase-8-like (NAT8L) and broken down in oligodendrocytes by aspartoacylase (ASPA) into acetate and aspartate. We have hypothesized that NAA links the metabolism of axons with oligodendrocytes to support myelination. To test this hypothesis, we performed lipidomic analyses using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and high-performance thin-layer chromatography (HPTLC) to identify changes in myelin lipid composition in postmortem MS brains and in NAT8L knockout (NAT8L

Indexed as

AcetyltransferasesAnimalsAspartic AcidCells, CulturedCentral Nervous SystemChromatography, LiquidFemaleGene Expression RegulationHistonesHumansKetoglutaric AcidsMaleMethylationMiceMice, Inbred C57BLMice, TransgenicAcetyltransferasesAspartic AcidHistonesKetoglutaric AcidsN-acetylaspartateShati protein, mouseHistone methylationMass spectrometryMultiple sclerosisMyelin lipidsN-acetylaspartateOligodendrocytes

Identifiers

PMID27709268
PMCPMC5875422
OpenAlexW2529252494

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.