Evidence map›Paper›PMID 27709196›Full record

ArticleChemical communications (Cambridge, England)2016

Nebraska Red: a phosphinate-based near-infrared fluorophore scaffold for chemical biology applications.

Xinqi Zhou, Rui Lai, Jon R Beck, Hui Li, Cliff I Stains

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed.

  1. Article
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  5. Optimizing multifunctional fluorescent ligands for intracellular labeling.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Ratio-based indicators for cytosolic CaProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. THQ-Xanthene: An Emerging Strategy to Create Next-Generation NIR-I/II Fluorophores.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xinqi ZhouDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. cstains2@unl.edu.
Rui LaiDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. cstains2@unl.edu and Nebraska Center for Materials and Nanoscience, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Jon R BeckDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. cstains2@unl.edu.
Hui LiDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. cstains2@unl.edu and Nebraska Center for Materials and Nanoscience, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Cliff I StainsDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. cstains2@unl.edu.

Funding

Chemical Approaches for Interrogating Fundamental Biomedical ProcessesR35GM119751 · NIGMS · UNIVERSITY OF VIRGINIA · PI STAINS, CLIFF I · 2016 to 2020
$1.8M
NIGMS NIH HHS R35 GM119751
6 · The paper itself

Abstract

A series of novel phosphinate-based dyes displaying near-infrared fluorescence (NIR) are reported. These dyes exhibit remarkable photostability and brightness. The phosphinate functionality is leveraged as an additional reactive handle in order to tune cell permeability as well as provide a proof-of-principle for a self-reporting small molecule delivery vehicle.

Indexed as

Cell Membrane PermeabilityDrug Delivery SystemsFluorescent DyesHeLa CellsHumansNanoparticlesPhosphinic AcidsReactive Nitrogen SpeciesReactive Oxygen SpeciesSpectroscopy, Near-InfraredFluorescent DyesPhosphinic AcidsReactive Nitrogen SpeciesReactive Oxygen Species

Identifiers

PMID27709196
PMCPMC5108567

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.