ArticlemSystems
Genetic and transcriptional analysis of human host response to healthy gut microbiota.
Article in mSystems. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Allogenic Faecal Microbiota Transfer Induces Immune-Related Gene Sets in the Colon Mucosa of Patients with Irritable Bowel Syndrome.Biomolecules · 2019Trial
- Host genotypes interact with microbial communities to modulate gene expression in the human intestine.medRxiv : the preprint server for health sciences · 2026Article
- Metabolic modeling and functional genomics reveal taxa and host gene interactions in colorectal cancer.bioRxiv : the preprint server for biology · 2026Article
- Host transcriptional responses to gut microbiome variation arising from urbanism.bioRxiv : the preprint server for biology · 2025Article
- Piceatannol Attenuates Benzo[Journal of agricultural and food chemistry · 2025Article
- Research progress on the interaction between intestinal flora and microRNA in pelvic inflammatory diseases.Non-coding RNA research · 2025Review
- The Role of Gut Microbiota in the Onset and Progression of Obesity and Associated Comorbidities.International journal of molecular sciences · 2024Review
- Dual Regulation Mechanism of Obesity: DNA Methylation and Intestinal Flora.Biomedicines · 2024Review
- Intestinal microbial circadian rhythms drive sex differences in host immunity and metabolism.iScience · 2023Article
- Article
- The relationship between the gut microbiome and host gene expression: a review.Human genetics · 2021Review
- Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine.Genomics, proteomics & bioinformatics · 2020Article
- Dietary cellulose induces anti-inflammatory immunity and transcriptional programs via maturation of the intestinal microbiota.Gut microbes · 2020Article
- Microbial control of host gene regulation and the evolution of host-microbiome interactions in primates.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Article
- A Novel View of HumanBiomolecules · 2019Review
- Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer development.Genome medicine · 2019Review
- An insight into gut microbiota and its functionalities.Cellular and molecular life sciences : CMLS · 2019Review
- Gluten-Free Diet: Gaps and Needs for a Healthier Diet.Nutrients · 2019Review
- Diet, Gut Microbiota, and Obesity: Links with Host Genetics and Epigenetics and Potential Applications.Advances in nutrition (Bethesda, Md.) · 2019Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Many studies have demonstrated the importance of the gut microbiota in healthy and disease states. However, establishing the causality of host-microbiota interactions in humans is still challenging. Here, we describe a novel experimental system to define the transcriptional response induced by the microbiota in human cells and to shed light on the molecular mechanisms underlying host-gut microbiota interactions. In primary human colonic epithelial cells, we identified over 6,000 genes that change expression at various time points following co-culturing with the gut microbiota of a healthy individual. Among the differentially expressed genes we found a 1.8-fold enrichment of genes associated with diseases that have been previously linked to the microbiome, such as obesity and colorectal cancer. In addition, our experimental system allowed us to identify 87 host SNPs that show allele-specific expression in 69 genes. Furthermore, for 12 SNPs in 12 different genes, allele-specific expression is conditional on the exposure to the microbiota. Of these 12 genes, eight have been associated with diseases linked to the gut microbiota, specifically colorectal cancer, obesity and type 2 diabetes. Our study demonstrates a scalable approach to study host-gut microbiota interactions and can be used to identify putative mechanisms for the interplay between host genetics and microbiota in health and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.