ArticleQuantitative imaging in medicine and surgery2016
Black blood T1rho MR imaging may diagnose early stage liver fibrosis: a proof-of-principle study with rat biliary duct ligation model.
Article in Quantitative imaging in medicine and surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Magnetic resonance T1ρ relaxation in patients with liver fibrosis: a systematic review and meta-analysis.Diagnostic and interventional radiology (Ankara, Turkey) · 2026Pooled it
- Stevioside promotes hepatocyte proliferation via YAP signaling in cholestatic disease.Acta pharmacologica Sinica · 2026Article
- T1rho MRI as a quantitative biomarker of radiation-induced liver disease in normal and fibrotic rat models.Quantitative imaging in medicine and surgery · 2026Article
- Multiparameter magnetic resonance imaging of liver fibrosis in a bile duct ligation mouse model.World journal of gastroenterology · 2021Article
- Physiological variation of liver iron concentration may not be dominantly responsible for the liver T1rho variations associated with age and gender.Quantitative imaging in medicine and surgery · 2021Article
- T1rho shortening effect of fat in liver steatosis after fat suppression: approximate estimation in a methionine and choline-deficient (MCD) diet rat model.Quantitative imaging in medicine and surgery · 2021Article
- Collagen deposition in the liver is strongly and positively associated with T1rho elongation while fat deposition is associated with T1rho shortening: an experimental study of methionine and choline-deficient (MCD) diet rat model.Quantitative imaging in medicine and surgery · 2020Article
- Liver injury monitoring, fibrosis staging and inflammation grading using T1rho magnetic resonance imaging: an experimental study in rats with carbon tetrachloride intoxication.BMC gastroenterology · 2020Article
- Topics on quantitative liver magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2019Review
- Combined morphological and functional liver MRI using spin-lattice relaxation in the rotating frame (T1ρ) in conjunction with Gadoxetic Acid-enhanced MRI.Scientific reports · 2019Article
- High performance of intravoxel incoherent motion diffusion MRI in detecting viral hepatitis-b induced liver fibrosis.Annals of translational medicine · 2019Article
- Decomposing the Mechanism of Qishen Granules in the Treatment of Heart Failure by a Quantitative Pathway Analysis Method.Molecules (Basel, Switzerland) · 2018Article
- How liver pathologies contribute to T1rho contrast require more careful studies.Quantitative imaging in medicine and surgery · 2017Article
- A comprehensive literatures update of clinical researches of superparamagnetic resonance iron oxide nanoparticles for magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2017Review
- Impact of Liver Fibrosis and Fatty Liver on T1rho Measurements: A Prospective Study.Korean journal of radiologyArticle
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6 authors.
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Abstract
backgroundTo explore black blood T1rho (T1ρ) liver imaging and investigate the earliest stage when biliary duct ligation (BDL) induced liver fibrosis can be diagnosed.
methodsMR was performed at 3 Tesla. A T1ρ prepared 2D fast spin echo (FSE) sequence with acquisition of four spin lock times (TSLs: 1, 10, 30, and 50 msec) and spin-lock frequency of 500 Hz was applied. Inherent black blood effect of FSE and double inversion recovery (DIR) achieved blood signal suppression, and 3 axial sections per liver were obtained. Male Sprague-Dawley rats were scanned at baseline (n=32), and on day-3 (n=13), day-5 (n=11), day-7 (n=10), day-10 (n=4) respectively after BDL. Hematoxylin-eosin (HE) and picrosirius red staining liver histology was obtained at these time points.
resultsThe physiological liver parenchyma T1ρ was 38.38±1.53 msec (range, 36.05-41.53 msec). Liver T1ρ value elevated progressively after BDL. On day-10 after BDL all experimental animals can be separated from normal liver based on T1ρ measurement with lowest value being 42.82 msec. Day-7 and day-10 liver resembled METAVIR stage-F1/F2 fibrosis, and fibrous area counted for 0.22%±0.13% and 0.38%±0.44% of liver parenchyma area, respectively.
conclusionsThis study provides the first proof-of-principle that T1ρ might diagnose early stage liver fibrosis.
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