Evidence map›Paper›PMID 27709019›Full record

ArticleActa pharmaceutica Sinica. B2016

17

Sung-Joon Cho, Miaoran Ning, Yanyan Zhang, Leah H Rubin, Hyunyoung Jeong

Open access · diamondAbstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sung-Joon ChoDepartment of Biopharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607, USA.
Miaoran NingDepartment of Biopharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607, USA.
Yanyan ZhangDepartment of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607, USA.
Leah H RubinDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL 60607, USA.
Hyunyoung JeongDepartment of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607, USA; Department of Biopharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607, USA.
University of Illinois Chicago · US

Funding

UIC Program for Interdisciplinary Careers in Women's Health ResearchK12HD055892 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GELLER, STACIE E. · 2007 to 2016
$4.9M
Altered drug metabolism in pregnancyR01HD065532 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI JEONG, HYUNYOUNG · 2011 to 2015
$1.7M
Molecular basis of interindividual variability in CYP2D6-mediated drug metabolismR01GM112746 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI JEONG, HYUNYOUNG · 2015 to 2018
$1.2M
NICHD NIH HHS K12 HD055892NICHD NIH HHS R01 HD065532NIGMS NIH HHS R01 GM112746
6 · The paper itself

Abstract

UDP-glucuronosyltransferase 1A9 (UGT1A9) is a major phase II enzyme responsible for elimination of drugs and endogenous molecules. Clinical data have shown increased elimination of UGT1A9 substrates in pregnant women or oral contraceptive users, but the role of estrogen in the regulation of UGT1A9 expression remains unknown. In this study, we investigated the effect of 17

Indexed as

17β-EstradiolDrug metabolismEstrogen receptorSex differenceUGT1A9

Identifiers

PMID27709019
PMCPMC5045538
OpenAlexW2404859779

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.