Evidence map›Paper›PMID 27709016›Full record

ArticleActa pharmaceutica Sinica. B2016

Effect of age on the pharmacokinetics of polymorphic nimodipine in rats after oral administration.

Wenli Liu, Xiaona Wang, Ruilian Chen, Kaixuan Zhang, Yao Li, Yi Li, Duanyun Si, Junbo Gong, Dianshu Yin, Yongli Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wenli LiuSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Xiaona WangSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Ruilian ChenSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Kaixuan ZhangSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Yao LiSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Yi LiSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Duanyun SiState Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China.
Junbo GongSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Dianshu YinPharmaceutical Research Institute, Shijiazhuang No. 4 Pharmaceutical Company, Shijiazhuang 052165, China.
Yongli WangSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Zhenping WeiSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Mingshi YangFaculty of Pharmaceutical Science, University of Copenhagen, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The previous investigation has proved that their existed pharmacokinetic difference between the different crystal forms of the polymorphic drugs after oral administration. However, no systemic investigations have been made on the change of this pharmacokinetic difference, resulted either from the physiological or from the pathological factors. In this paper, we used polymorphic nimodipine (Nim) as a model drug and investigated the effect of age difference (2- and 9-month old) on the pharmacokinetics after oral delivery in rats. As the results shown, for L-form of Nim (L-Nim), the AUC

Indexed as

Age differenceCrystal formNimodipinePharmacokineticsPolymorphic drug

Identifiers

PMID27709016
PMCPMC5045546

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.