Evidence map›Paper›PMID 27708965›Full record

ReviewEuropean journal of rheumatology2016

Viral hepatitis screening guideline before biological drug use in rheumatic patients.

Ömer Karadağ, Timuçin Kaşifoğlu, Birol Özer, Sabahattin Kaymakoğlu, Yeşim Kuş, Murat İnanç, Gökhan Keser, Sedat Kiraz

Open access · diamondAbstract readReview
In one paragraph

Review in European journal of rheumatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Gaps in Ambulatory Patient Safety for Immunosuppressive Specialty Medications.Joint Commission journal on quality and patient safety · 2019
    Article
  9. Article
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Ömer KaradağDepartment of Internal Medicine, Division of Rheumatology, Hacettepe University School of Medicine, Ankara, Turkey.
Timuçin KaşifoğluDepartment of Internal Medicine, Division of Rheumatology, Osmangazi University School of Medicine, Eskişehir, Turkey.
Birol ÖzerDepartment of Gastroenterology, Başkent University, School of Medicine, Adana, Turkey.
Sabahattin KaymakoğluDepartment of Gastroenterohepatology, İstanbul University School of Medicine, İstanbul, Turkey.
Yeşim KuşSenior Scientific Advisor at Bristol-Myers Squibb, İstanbul, Turkey.
Murat İnançDepartment of Internal Medicine, Division of Rheumatology, İstanbul University School of Medicine, İstanbul, Turkey.
Gökhan KeserDepartment of Internal Medicine, Division of Rheumatology, Ege University School of Medicine, İzmir, Turkey.
Sedat KirazDepartment of Internal Medicine, Division of Rheumatology, Hacettepe University School of Medicine, Ankara, Turkey.
Hacettepe University · TRIstanbul University · TRBaşkent University · TREge University · TREskişehir Osmangazi University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biological drugs (tumor necrosis factor inhibitors, rituximab, tocilizumab, abatacept, and tofacitinib) are important treatment alternatives in rheumatology, particularly for resistant patients. However, they may cause hepatitis B virus (HBV) and hepatitis C virus (HCV) reactivation; for instance, HBV reactivation may occur in a patient who is an inactive hepatitis B surface antigen (HBsAg) carrier or who has resolved HBV infection. Therefore, the screening of patients before biological treatment and the application of a prophylactic treatment, particularly with respect to latent HBV infections, are recommended when necessary. This guideline covers pre-treatment screening and follow-up recommendations, if required, with respect to viral hepatitides in rheumatology patients who are planned to be given biological drugs. Although this guideline is prepared for biological disease-modifying antirheumatic drugs (DMARDs), it is recommended to be used also for target-oriented DMARDS and medium-high dose corticosteroids (>7.5 mg prednisolone/day equivalent). It should be considered that the reactivation risk is higher when more than one immunosuppressive drug is used.

Indexed as

biologic drugsrheumatic patientsViral hepatitis

Identifiers

PMID27708965
PMCPMC5042270
OpenAlexW2528841592

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.