ArticleInterface focus2016
Comparison of cell migration mechanical strategies in three-dimensional matrices: a computational study.
Article in Interface focus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- A multiscale theory for mesenchymal cell migration in straight or curved channel confinement.Biophysical journal · 2025Article
- Emergence of multiple collective motility modes in a physical model of cell chains.NPJ systems biology and applications · 2025Article
- A Simple Framework for Agent-Based Modeling with Extracellular Matrix.Bulletin of mathematical biology · 2025Article
- Optogenetically engineered Septin-7 enhances immune cell infiltration of tumor spheroids.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Three-component contour dynamics model to simulate and analyze amoeboid cell motility in two dimensions.PloS one · 2024Article
- The evolution and diversity of actin-dependent cell migration.Molecular biology of the cell · 2023Review
- A computational model for the transit of a cancer cell through a constricted microchannel.Biomechanics and modeling in mechanobiology · 2023Article
- Identification of a novel type of focal adhesion remodelling via FAK/FRNK replacement, and its contribution to cancer progression.Cell death & disease · 2023Article
- Unravelling cell migration: defining movement from the cell surface.Cell adhesion & migration · 2022Review
- T cell morphodynamics reveal periodic shape oscillations in three-dimensional migration.Journal of the Royal Society, Interface · 2022Article
- A computational modeling of invadopodia protrusion into an extracellular matrix fiber network.Scientific reports · 2022Article
- 3D Bioprinting of Cell-Laden Hydrogels for Improved Biological Functionality.Advanced materials (Deerfield Beach, Fla.) · 2022Review
- Matrix-driven changes in metabolism support cytoskeletal activity to promote cell migration.Biophysical journal · 2021Article
- Restraint of Human Skin Fibroblast Motility, Migration, and Cell Surface Actin Dynamics, by Pannexin 1 and P2X7 Receptor Signaling.International journal of molecular sciences · 2021Article
- Recent advances in understanding the role of metabolic heterogeneities in cell migration.Faculty reviews · 2021Review
- Tools for computational analysis of moving boundary problems in cellular mechanobiology.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- Nuclear plasticity increases susceptibility to damage during confined migration.PLoS computational biology · 2020Article
- Evaluation of Cell's Passability in the ECM Network.Biophysical journal · 2020Article
- Computational estimates of mechanical constraints on cell migration through the extracellular matrix.PLoS computational biology · 2020Article
- The WAVE Regulatory Complex Is Required to Balance Protrusion and Adhesion in Migration.Cells · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell migration on a two-dimensional flat surface has been extensively studied and is generally characterized by a front-protrusion-rear-contraction process. In a three-dimensional (3D) environment, on the other hand, cells adopt multiple migration strategies depending on the cell type and the properties of the extracellular matrix (ECM). By using computer simulations, we find that these migration strategies can be classified by various spatial-temporal dynamics of actin protrusion, actin-myosin contraction and actin-ECM adhesion. We demonstrate that if we include or exclude proteolysis of ECM, and vary adhesion dynamics and spatial distributions of protrusion, contraction and adhesion, our model can reproduce six experimentally observed motility modes: mesenchymal, chimneying, amoeboid, blebbing, finger-like protrusion and rear-squeezing cell locomotory behaviours. We further find that the mode of the cell motility evolves in response to the ECM density and adhesion detachment rate. The model makes non-trivial predictions about cell speed as a function of the adhesion strength, and ECM elasticity and mesh size.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.