ArticleInterface focus2016
Multimodality imaging and mathematical modelling of drug delivery to glioblastomas.
Article in Interface focus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Advancing Tumor Treatment Through Artificial Intelligence and Mathematical Modeling: A Comprehensive Review.Health science reports · 2026Article
- Comparison of contrast-enhanced ultrasound imaging (CEUS) and super-resolution ultrasound (SRU) for the quantification of ischaemia flow redistribution: a theoretical study.Physics in medicine and biology · 2024Article
- Histology-guided mathematical model of tumor oxygenation: sensitivity analysis of physical and computational parameters.bioRxiv : the preprint server for biology · 2024Article
- Measurement and Modeling of Transport Across the Blood-Brain Barrier.Journal of biomechanical engineering · 2023Review
- Predictive Design and Analysis of Drug Transport by Multiscale Computational Models Under Uncertainty.Pharmaceutical research · 2023Review
- Liquid biopsies for early diagnosis of brain tumours:Journal of the Royal Society, Interface · 2022Article
- Glioma facilitates the epileptic and tumor-suppressive gene expressions in the surrounding region.Scientific reports · 2022Article
- Vascular normalisation as the stepping stone into tumour microenvironment transformation.British journal of cancer · 2021Review
- Bridging cell-scale simulations and radiologic images to explain short-time intratumoral oxygen fluctuations.PLoS computational biology · 2021Article
- An in-silico study of cancer cell survival and spatial distribution within a 3D microenvironment.Scientific reports · 2020Article
- Dendritic cells transduced with glioma-expressed antigen 2 recombinant adenovirus induces specific cytotoxic lymphocyte response and anti-tumor effect in mice.Journal of inflammation (London, England) · 2020Article
- Hybrid modeling frameworks of tumor development and treatment.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- Super-Resolution Contrast-Enhanced Ultrasound Methodology for the Identification of In Vivo Vascular Dynamics in 2D.Investigative radiology · 2019Article
- Established and Emerging Strategies for Drug Delivery Across the Blood-Brain Barrier in Brain Cancer.Pharmaceutics · 2019Review
- The need for mathematical modelling of spatial drug distribution within the brain.Fluids and barriers of the CNS · 2019Review
- Tumor Ensemble-Based Modeling and Visualization of Emergent Angiogenic Heterogeneity in Breast Cancer.Scientific reports · 2019Article
- The many faces of mathematical modelling in oncology.The British journal of radiology · 2019Review
- Adaptation to Stochastic Temporal Variations in Intratumoral Blood Flow: The Warburg Effect as a Bet Hedging Strategy.Bulletin of mathematical biology · 2018Article
- Towards personalized computational oncology: from spatial models of tumour spheroids, to organoids, to tissues.Journal of the Royal Society, Interface · 2018Review
- Principles of Simultaneous PET/MR Imaging.Magnetic resonance imaging clinics of North America · 2017Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Patients diagnosed with glioblastoma, an aggressive brain tumour, have a poor prognosis, with a median overall survival of less than 15 months. Vasculature within these tumours is typically abnormal, with increased tortuosity, dilation and disorganization, and they typically exhibit a disrupted blood-brain barrier (BBB). Although it has been hypothesized that the 'normalization' of the vasculature resulting from anti-angiogenic therapies could improve drug delivery through improved blood flow, there is also evidence that suggests that the restoration of BBB integrity might limit the delivery of therapeutic agents and hence their effectiveness. In this paper, we apply mathematical models of blood flow, vascular permeability and diffusion within the tumour microenvironment to investigate the effect of these competing factors on drug delivery. Preliminary results from the modelling indicate that all three physiological parameters investigated-flow rate, vessel permeability and tissue diffusion coefficient-interact nonlinearly to produce the observed average drug concentration in the microenvironment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.