Evidence map›Paper›PMID 27708760›Full record

ArticleInterface focus2016

Local modulation of chemoattractant concentrations by single cells: dissection using a bulk-surface computational model.

J A Mackenzie, M Nolan, R H Insall

Abstract read
In one paragraph

Article in Interface focus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. An Adaptive Moving Mesh Method for Forced Curve Shortening Flow.SIAM journal on scientific computing : a publication of the Society for Industrial and Applied Mathematics · 2019
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

J A MackenzieDepartment of Mathematics and Statistics , University of Strathclyde , Glasgow G1 1XH , UK.ORCID 0000-0003-4412-7057
M NolanDepartment of Mathematics and Statistics , University of Strathclyde , Glasgow G1 1XH , UK.
R H InsallBeatson Institute for Cancer Research , Switchback Road, Bearsden G61 1BD , UK.ORCID 0000-0003-4898-040X

Funding

Cancer Research UK 15672Cancer Research UK 20017
6 · The paper itself

Abstract

Chemoattractant gradients are usually considered in terms of sources and sinks that are independent of the chemotactic cell. However, recent interest has focused on 'self-generated' gradients, in which cell populations create their own local gradients as they move. Here, we consider the interplay between chemoattractants and single cells. To achieve this, we extend a recently developed computational model to incorporate breakdown of extracellular attractants by membrane-bound enzymes. Model equations are parametrized, using the published estimates from

Indexed as

bulk-surface modelcell motilitychemotaxisself-generated gradientssurface finite-elements

Identifiers

PMID27708760
PMCPMC4992739

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.