Evidence map›Paper›PMID 27708722›Full record

ArticleClinical epigenetics2016

Emily Eva Holmes, Diane Goltz, Verena Sailer, Maria Jung, Sebastian Meller, Barbara Uhl, Jörn Dietrich, Magda Röhler, Jörg Ellinger, Glen Kristiansen and 1 more

Open access · goldAbstract read
In one paragraph

Article in Clinical epigenetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Methylation Subtypes of Primary Prostate Cancer Predict Poor Prognosis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022
    Article
  9. The expression and methylation ofFrontiers in genetics · 2022
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Clinical epigenetics · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Emily Eva Holmes *Institute of Pathology, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
Diane Goltz *Institute of Pathology, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
Verena SailerDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine of Cornell University, New York, NY USA.
Maria JungInstitute of Pathology, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
Sebastian MellerInstitute of Pathology, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
Barbara UhlInstitute of Pathology, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
Jörn DietrichDepartment of Otolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany.
Magda RöhlerInstitute of Pathology, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
Jörg EllingerDepartment of Urology, University Hospital Bonn, Bonn, Germany.
Glen Kristiansen *Institute of Pathology, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
Dimo Dietrich *Institute of Pathology, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
University Hospital Bonn · DECornell University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMolecular biomarkers that might help to distinguish between more aggressive and clinically insignificant prostate cancers (PCa) are still urgently needed. Aberrant DNA methylation as a common molecular alteration in PCa seems to be a promising source for such biomarkers. In this study,

methods

resultsIn PCa tissue,

conclusions

Indexed as

DNA MethylationDisease-Free SurvivalGenetic MarkersHomeobox Protein PITX2Homeodomain ProteinsHumansMalePrognosisPromoter Regions, GeneticProstatectomyProstatic NeoplasmsRetrospective StudiesSurvival AnalysisTranscription FactorsGenetic MarkersHomeobox Protein PITX2homeobox protein PITX3Homeodomain ProteinsTranscription FactorsDNA methylationPITX2PITX3Prognostic biomarkerProstate cancer

Identifiers

PMID27708722
PMCPMC5037587
OpenAlexW2524051202

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.