Evidence map›Paper›PMID 27708560›Full record

ArticleFrontiers in neuroscience2016

Targeted Re-Sequencing Approach of Candidate Genes Implicates Rare Potentially Functional Variants in Tourette Syndrome Etiology.

John Alexander, Hera Potamianou, Jinchuan Xing, Li Deng, Iordanis Karagiannidis, Fotis Tsetsos, Petros Drineas, Zsanett Tarnok, Renata Rizzo, Tomasz Wolanczyk and 14 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Molecular Landscape of Tourette's Disorder.International journal of molecular sciences · 2023
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Association of Rare Genetic Variants in Opioid Receptors with Tourette Syndrome.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 11 institutions in 6 countries.

John AlexanderDepartment of Molecular Biology and Genetics, Democritus University of Thrace Alexandroupoli, Greece.
Hera PotamianouDepartment of Molecular Biology and Genetics, Democritus University of Thrace Alexandroupoli, Greece.
Jinchuan XingDepartment of Genetics, Rutgers, The State University of New JerseyPiscataway, NJ, USA; Human Genetics Institute of New Jersey, Rutgers, The State University of New JerseyPiscataway, NJ, USA.
Li DengDepartment of Genetics, Rutgers, The State University of New JerseyPiscataway, NJ, USA; Human Genetics Institute of New Jersey, Rutgers, The State University of New JerseyPiscataway, NJ, USA.
Iordanis KaragiannidisDepartment of Molecular Biology and Genetics, Democritus University of Thrace Alexandroupoli, Greece.
Fotis TsetsosDepartment of Molecular Biology and Genetics, Democritus University of Thrace Alexandroupoli, Greece.
Petros DrineasComputer Science Department, Purdue University West Lafayette, USA.
Zsanett TarnokVadaskert Clinic for Child and Adolescent Psychiatry Budapest, Hungary.
Renata RizzoDepartment of Clinical and Experimental Medicine, University of Catania Catania, Italy.
Tomasz WolanczykDepartment of Child Psychiatry, Medical University of Warsaw Warsaw, Poland.
Luca FarkasVadaskert Clinic for Child and Adolescent Psychiatry Budapest, Hungary.
Peter NagyVadaskert Clinic for Child and Adolescent Psychiatry Budapest, Hungary.
Urszula SzymanskaDepartment of Child Psychiatry, Medical University of Warsaw Warsaw, Poland.
Christos AndroutsosChild and Adolescent Psychiatry Clinic, Sismanoglio General Hospital of Attica Athens, Greece.
Vaia TsironiChild and Adolescent Psychiatry Clinic, Sismanoglio General Hospital of Attica Athens, Greece.
Anastasia KoumoulaChild and Adolescent Psychiatry Clinic, Sismanoglio General Hospital of Attica Athens, Greece.
Csaba BartaMolecular Biology and Pathobiochemistry, Institute of Medical Chemistry, Semmelweis University Budapest, Hungary.
TSGeneSEE
Paul SandorDepartment of Psychiatry, University of Toronto Toronto, ON, Canada.
Cathy L BarrGenetics and Development Division, Krembil Research Institute, University Health NetworkToronto, ON, Canada; Program in Neurosciences and Mental Health, The Hospital for Sick ChildrenToronto, ON, Canada.
Jay TischfieldDepartment of Genetics, Rutgers, The State University of New JerseyPiscataway, NJ, USA; Human Genetics Institute of New Jersey, Rutgers, The State University of New JerseyPiscataway, NJ, USA.
Peristera PaschouDepartment of Molecular Biology and Genetics, Democritus University of Thrace Alexandroupoli, Greece.
Gary A HeimanDepartment of Genetics, Rutgers, The State University of New JerseyPiscataway, NJ, USA; Human Genetics Institute of New Jersey, Rutgers, The State University of New JerseyPiscataway, NJ, USA.
Marianthi GeorgitsiDepartment of Molecular Biology and Genetics, Democritus University of ThraceAlexandroupoli, Greece; Laboratory of General Biology, Department of Medicine, Aristotle University of ThessalonikiThessaloniki, Greece.
Democritus University of Thrace · GRRutgers, The State University of New Jersey · USSismanoglio General Hospital · GRVadaskert Alapítvány a Gyermekek Lelki Egészségéért · HUMedical University of Warsaw · PLAristotle University of Thessaloniki · GRKrembil Research InstitutePurdue University West Lafayette · USSemmelweis University · HUUniversity of Catania · ITUniversity of Toronto · CA

Funding

NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8M
1/8-Collaborative genomic studies of Tourette DisorderR01MH092293 · NIMH · RUTGERS, THE STATE UNIV OF N.J. · PI HEIMAN, GARY A., TISCHFIELD, JAY ARNOLD · 2011 to 2013
$510k
NIMH NIH HHS R01 MH092293NIMH NIH HHS U24 MH068457
6 · The paper itself

Abstract

Although the genetic basis of Tourette Syndrome (TS) remains unclear, several candidate genes have been implicated. Using a set of 382 TS individuals of European ancestry we investigated four candidate genes for TS (

Indexed as

genetic susceptibilityHDCnext generation sequencingrare variantsSLITRK1targeted re-sequencingTS candidate genes

Identifiers

PMID27708560
PMCPMC5030307
OpenAlexW2522515907

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.