Evidence map›Paper›PMID 27708515›Full record

ArticleAnnals of gastroenterology

Irritable bowel syndrome might be associated with dry eye disease.

Ioannis Asproudis, Anthoula T Tsoumani, Konstantinos H Katsanos, Aristeidis H Katsanos, Vasileios Theopistos, Konstantinos A Paschidis, Epameinondas V Tsianos, Dimitrios Christodoulou

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Corneal neuropathic pain in irritable bowel syndrome: clinical findings and in vivo corneal confocal microscopy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ioannis AsproudisDepartment of Ophthalmology, Medical School (Ioannis Asproudis, Anthoula T. Tsoumani, Konstantinos A. Paschidis), University of Ioannina Medical School, Ioannina, Greece.
Anthoula T TsoumaniDepartment of Ophthalmology, Medical School (Ioannis Asproudis, Anthoula T. Tsoumani, Konstantinos A. Paschidis), University of Ioannina Medical School, Ioannina, Greece.
Konstantinos H Katsanos1 Division of Internal Medicine and Hepato-Gastroenterology Unit (Konstantinos H. Katsanos, Vasileios Theopistos, Epameinondas V. Tsianos, Dimitrios Christodoulou), University of Ioannina Medical School, Ioannina, Greece.
Aristeidis H KatsanosDepartment of Neurology (Aristeidis H. Katsanos), University of Ioannina Medical School, Ioannina, Greece.
Vasileios Theopistos1 Division of Internal Medicine and Hepato-Gastroenterology Unit (Konstantinos H. Katsanos, Vasileios Theopistos, Epameinondas V. Tsianos, Dimitrios Christodoulou), University of Ioannina Medical School, Ioannina, Greece.
Konstantinos A PaschidisDepartment of Ophthalmology, Medical School (Ioannis Asproudis, Anthoula T. Tsoumani, Konstantinos A. Paschidis), University of Ioannina Medical School, Ioannina, Greece.
Epameinondas V Tsianos1 Division of Internal Medicine and Hepato-Gastroenterology Unit (Konstantinos H. Katsanos, Vasileios Theopistos, Epameinondas V. Tsianos, Dimitrios Christodoulou), University of Ioannina Medical School, Ioannina, Greece.
Dimitrios Christodoulou1 Division of Internal Medicine and Hepato-Gastroenterology Unit (Konstantinos H. Katsanos, Vasileios Theopistos, Epameinondas V. Tsianos, Dimitrios Christodoulou), University of Ioannina Medical School, Ioannina, Greece.
University of Ioannina · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA possible association between dry eye disease (DED) and irritable bowel syndrome (IBS) has been hypothesized based on the fact that they both share an inflammatory pathogenesis.

methodsNinety-five patients with IBS and 276 healthy controls were enrolled in the study. All patients answered a questionnaire regarding DED symptoms and had a complete ophthalmic examination. DED signs were evaluated using Schirmer's 1 and tear break-up time (tBUT) tests in both groups.

resultsFemale IBS participants presented significantly lower Schirmer's test and tBUT (P=0.002 and P<0.001 respectively) than controls. Both diagnostic tests in male IBS patients were also significantly lower than in controls (P<0.001). 72% of IBS patients gave at least 3 positive answers to the questionnaire compared with 42% of the control group (P<0.01).

conclusionOur results suggest a correlation between IBS and DED. DED symptoms can cause further complications in patients with IBS, and should be considered in their management. However, further research is needed to establish a possible pathophysiologic association.

Indexed as

Dry eyeirritable bowel syndromekeratoconjunctivitis sicca

Identifiers

PMID27708515
PMCPMC5049556
OpenAlexW2436550536

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.