Mammary development, hyperestrogenemia, and hypocortisolemia in a male cat with an adrenal cortical carcinoma.

Amy C Nadolski, Jessica E Markovich, Samuel H Jennings, Orla M Mahony

Open access · greenAbstract readCase Reports

In one paragraph

Article in The Canadian veterinary journal = La revue veterinaire canadienne, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it

0cells of the map it votes in

8citing papers in PubMed

0.9field-weighted citation impact, top 22% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

Persistent estrus signs in a spayed bitch following coexistence of ovarian remnant syndrome and exposure to exogenous estrogen: a case report.Veterinary research communications · 2026
Article
Granulosa Cell Tumour in a Spayed Cat With Ovarian Remnant Syndrome and Hyperestrogenaemia Without Estrus Signs.Veterinary medicine and science · 2026
Article
Case report: Androgen-secreting adrenocortical tumors in eight cats.Frontiers in veterinary science · 2023
Article
A review of adverse events in animals and children after secondary exposure to transdermal hormone-containing medicinal products.Veterinary record open · 2022
Review
Sex-hormone producing adrenal tumors causing behavioral changes as the sole clinical sign in 3 cats.The Canadian veterinary journal = La revue veterinaire canadienne · 2019
Article
Hyperandrogenism associated with an ovarian remnant in a spayed female cat.JFMS open reports
Article
A case of behavioral changes in a castrated male cat due to a functional adrenocortical adenoma producing testosterone and androstenedione.JFMS open reports
Article
Gynaecomastia in a male neutered cat with an adrenal tumour and associated hyperprogesteronism, hypercortisolism and hyperaldosteronism.JFMS open reports
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Amy C NadolskiVCA Emergency Animal Hospital and Referral Center, 2317 Hotel Circle South, San Diego, California 92111, USA (Nadolski); VCA Animal Referral and Emergency Center of Arizona, Mesa, Arizona, USA (Markovich); Department of Biomedical Sciences (Jennings), Department of Clinical Sciences (Mahony), Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA.

Jessica E MarkovichVCA Emergency Animal Hospital and Referral Center, 2317 Hotel Circle South, San Diego, California 92111, USA (Nadolski); VCA Animal Referral and Emergency Center of Arizona, Mesa, Arizona, USA (Markovich); Department of Biomedical Sciences (Jennings), Department of Clinical Sciences (Mahony), Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA.

Samuel H JenningsVCA Emergency Animal Hospital and Referral Center, 2317 Hotel Circle South, San Diego, California 92111, USA (Nadolski); VCA Animal Referral and Emergency Center of Arizona, Mesa, Arizona, USA (Markovich); Department of Biomedical Sciences (Jennings), Department of Clinical Sciences (Mahony), Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA.

Orla M MahonyVCA Emergency Animal Hospital and Referral Center, 2317 Hotel Circle South, San Diego, California 92111, USA (Nadolski); VCA Animal Referral and Emergency Center of Arizona, Mesa, Arizona, USA (Markovich); Department of Biomedical Sciences (Jennings), Department of Clinical Sciences (Mahony), Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA.

California Animal Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 14-year-old neutered male domestic shorthaired cat was diagnosed with an adrenal cortical carcinoma causing hyperestrogenemia that resulted in mammary hyperplasia and sexual behavior. A right adrenalectomy and mammary gland biopsy were performed. Adrenal cortical neoplasia should be ruled out in any neutered male cat with mammary development and/or exhibiting sexual behavior.

Indexed as

Adrenal Cortex NeoplasmsAdrenalectomyAnimalsCarcinomaCat DiseasesCatsEstrogensHydrocortisoneMaleMammary Glands, AnimalEstrogensHydrocortisone

Identifiers

PMID27708447

PMCPMC5026149

OpenAlexW2557895188

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.