ArticleScientific reports2016
Loss of Atg16 delays the alcohol-induced sedation response via regulation of Corazonin neuropeptide production in Drosophila.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Molecular mechanism on autophagy associated cardiovascular dysfunction inFrontiers in cell and developmental biology · 2025Review
- Corazonin Stimulates Ecdysteroid Synthesis during the Molting Process of the Swimming Crab,Biology · 2024Article
- The nonautophagic functions of autophagy-related proteins.Autophagy · 2024Review
- The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS complex and regulates autophagy.Communications biology · 2024Article
- Autophagy protein ATG-16.2 and its WD40 domain mediate the beneficial effects of inhibiting early-acting autophagy genes in C. elegans neurons.Nature aging · 2024Article
- Review
- LC3-associated phagocytosis promotes glial degradation of axon debris after injury in Drosophila models.Nature communications · 2023Article
- Loss of ubiquitinated protein autophagy is compensated by persistent cnc/NFE2L2/Nrf2 antioxidant responses.Autophagy · 2022Article
- Autophagy controlsFrontiers in cell and developmental biology · 2022Article
- Corazonin Neurons Contribute to Dimorphic Ethanol Sedation Sensitivity inFrontiers in neural circuits · 2022Article
- Macroautophagy and normal aging of the nervous system: Lessons from animal models.Cell stress · 2021Review
- Article
- GnRH-Related Neurohormones in the Fruit FlyInternational journal of molecular sciences · 2021Review
- Maternal GABAergic and GnRH/corazonin pathway modulates egg diapause phenotype of the silkwormProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Maintaining mitochondria in beige adipose tissue.Adipocyte · 2019Review
- On the Fly: Recent Progress on Autophagy and Aging in Drosophila.Frontiers in cell and developmental biology · 2019Review
- Review
- A Fly's Eye View of Natural and Drug Reward.Frontiers in physiology · 2018Review
- UsingBioMed research international · 2018Review
- Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
Autophagy defects lead to the buildup of damaged proteins and organelles, reduced survival during starvation and infections, hypersensitivity to stress and toxic substances, and progressive neurodegeneration. Here we show that, surprisingly, Drosophila mutants lacking the core autophagy gene Atg16 are not only defective in autophagy but also exhibit increased resistance to the sedative effects of ethanol, unlike Atg7 or Atg3 null mutant flies. This mutant phenotype is rescued by the re-expression of Atg16 in Corazonin (Crz)-producing neurosecretory cells that are known to promote the sedation response during ethanol exposure, and RNAi knockdown of Atg16 specifically in these cells also delays the onset of ethanol-induced coma. We find that Atg16 and Crz colocalize within these neurosecretory cells, and both Crz protein and mRNA levels are decreased in Atg16 mutant flies. Thus, Atg16 promotes Crz production to ensure a proper organismal sedation response to ethanol.
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