Evidence map›Paper›PMID 27708404›Full record

ArticleScientific reports2016

Replenishment of microRNA-188-5p restores the synaptic and cognitive deficits in 5XFAD Mouse Model of Alzheimer's Disease.

Kihwan Lee, Hyunju Kim, Kyongman An, Oh-Bin Kwon, Sungjun Park, Jin Hee Cha, Myoung-Hwan Kim, Yoontae Lee, Joung-Hun Kim, Kwangwook Cho and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. MicroRNAs in neurodegenerative diseases: from molecular mechanisms to clinical biomarkers, detection methods and therapeutic strategies-advances and challenges.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  9. MicroRNAs and synaptic dysfunction in Parkinson's disease.Molecular therapy. Nucleic acids · 2025
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Roles of Non-Coding RNA in Alzheimer's Disease Pathophysiology.International journal of molecular sciences · 2023
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Kihwan LeeDepartment of Pharmacology, College of Medicine, Seoul National University, Seoul, 110-799, Republic of Korea.
Hyunju KimDepartment of Pharmacology, College of Medicine, Seoul National University, Seoul, 110-799, Republic of Korea.
Kyongman AnDepartment of Life Science, POSTECH, Pohang, Gyeongbuk, 790-784, Republic of Korea.
Oh-Bin KwonDepartment of Life Science, POSTECH, Pohang, Gyeongbuk, 790-784, Republic of Korea.
Sungjun ParkDepartment of Life Science, POSTECH, Pohang, Gyeongbuk, 790-784, Republic of Korea.
Jin Hee ChaDepartment of Physiology, College of Medicine, Seoul National University, Seoul, 110-799, Republic of Korea.
Myoung-Hwan KimDepartment of Physiology, College of Medicine, Seoul National University, Seoul, 110-799, Republic of Korea.
Yoontae LeeDepartment of Life Science, POSTECH, Pohang, Gyeongbuk, 790-784, Republic of Korea.
Joung-Hun KimDepartment of Life Science, POSTECH, Pohang, Gyeongbuk, 790-784, Republic of Korea.
Kwangwook ChoHenry Wellcome Laboratories for Integrative Neuroscience and Endocrinology (LINE), Faculty of Medicine and Dentistry, University of Bristol, Whitson Street, Bristol BS1 3NY, UK.
Hye-Sun KimDepartment of Pharmacology, College of Medicine, Seoul National University, Seoul, 110-799, Republic of Korea.
Pohang University of Science and Technology · KRSeoul National University · KRSeoul National University Bundang Hospital · KRUniversity of Bristol · GB

Funding

Biotechnology and Biological Sciences Research Council BB/G003963/1Medical Research CouncilWellcome Trust
6 · The paper itself

Abstract

MicroRNAs have emerged as key factors in development, neurogenesis and synaptic functions in the central nervous system. In the present study, we investigated a pathophysiological significance of microRNA-188-5p (miR-188-5p) in Alzheimer's disease (AD). We found that oligomeric Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesCognitive DysfunctionHippocampusMicroRNAsPeptide FragmentsSynapsesAnimalsDisease Models, AnimalHumansMaleMiceMice, TransgenicNeuronsAmyloid beta-Peptidesamyloid beta-protein (1-42)MicroRNAsMIRN188 microRNA, mousePeptide Fragments

Identifiers

PMID27708404
PMCPMC5052619
OpenAlexW2527776658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.