ArticleScientific reports2016
Weighted and directed interactions in evolving large-scale epileptic brain networks.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Transcutaneous auricular vagus nerve stimulation induces stabilizing modifications in large-scale functional brain networks: towards understanding the effects of taVNS in subjects with epilepsy.Scientific reports · 2021Trial
- Reconfiguration of human evolving large-scale epileptic brain networks prior to seizures: an evaluation with node centralities.Scientific reports · 2020Trial
- sEEG-guided responsive neurostimulation to treat neocortical epilepsy: A multicenter retrospective study of the efficacy and safety of depth electrode-mediated neuromodulation.Epilepsia open · 2026Article
- Stable Yet Destabilised: Towards Understanding Brain Network Dynamics in Psychogenic Disorders.Journal of clinical medicine · 2025Article
- Spatial and spectral structure of local functional connectivity of the background intracranial EEG in patients with focal epilepsy.Frontiers in network physiology · 2025Article
- A Case Study on EEG Signal Correlation Towards Potential Epileptic Foci Triangulation.Sensors (Basel, Switzerland) · 2024Article
- The time-evolving epileptic brain network: concepts, definitions, accomplishments, perspectives.Frontiers in network physiology · 2023Review
- Stimulation-related modifications of evolving functional brain networks in unresponsive wakefulness.Scientific reports · 2022Article
- Electrodermal Activity Biofeedback Alters Evolving Functional Brain Networks in People With Epilepsy, but in a Non-specific Manner.Frontiers in neuroscience · 2022Article
- Brain functional network modeling and analysis based on fMRI: a systematic review.Cognitive neurodynamics · 2021Review
- Impact of Transcutaneous Auricular Vagus Nerve Stimulation on Large-Scale Functional Brain Networks: From Local to Global.Frontiers in physiology · 2021Article
- Astroglial Glutamine Synthetase and the Pathogenesis of Mesial Temporal Lobe Epilepsy.Frontiers in neurology · 2021Review
- The Human Organism as an Integrated Interaction Network: Recent Conceptual and Methodological Challenges.Frontiers in physiology · 2020Article
- Pilot Study of An Intracranial Electroencephalography Biomarker of Depressive Symptoms in Epilepsy.The Journal of neuropsychiatry and clinical neurosciences · 2020Article
- Astrocytes and Glutamine Synthetase in Epileptogenesis.Journal of neuroscience research · 2019Review
- Precursors of seizures due to specific spatial-temporal modifications of evolving large-scale epileptic brain networks.Scientific reports · 2019Article
- Association of Seizure Spread With Surgical Failure in Epilepsy.JAMA neurology · 2019Article
- Traceability and dynamical resistance of precursor of extreme events.Scientific reports · 2019Article
- Connectivity strength, time lag structure and the epilepsy network in resting-state fMRI.NeuroImage. Clinical · 2019Article
- Seizure prediction - ready for a new era.Nature reviews. Neurology · 2018Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epilepsy can be regarded as a network phenomenon with functionally and/or structurally aberrant connections in the brain. Over the past years, concepts and methods from network theory substantially contributed to improve the characterization of structure and function of these epileptic networks and thus to advance understanding of the dynamical disease epilepsy. We extend this promising line of research and assess-with high spatial and temporal resolution and using complementary analysis approaches that capture different characteristics of the complex dynamics-both strength and direction of interactions in evolving large-scale epileptic brain networks of 35 patients that suffered from drug-resistant focal seizures with different anatomical onset locations. Despite this heterogeneity, we find that even during the seizure-free interval the seizure onset zone is a brain region that, when averaged over time, exerts strongest directed influences over other brain regions being part of a large-scale network. This crucial role, however, manifested by averaging on the population-sample level only - in more than one third of patients, strongest directed interactions can be observed between brain regions far off the seizure onset zone. This may guide new developments for individualized diagnosis, treatment and control.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.