ArticleScientific reports2016
Increasing The Genetic Admixture of Available Lines of Human Pluripotent Stem Cells.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Silenced genomes.Nature medicine · 2026Article
- Biotechnological advances and applications of human pluripotent stem cell-derived heart models.Frontiers in bioengineering and biotechnology · 2023Review
- Greater genetic diversity is needed in human pluripotent stem cell models.Nature communications · 2022Article
- Defective hematopoietic differentiation of immune aplastic anemia patient-derived iPSCs.Cell death & disease · 2022Article
- Dense optical flow software to quantify cellular contractility.Cell reports methods · 2021Article
- Ancestry-dependent gene expression correlates with reprogramming to pluripotency and multiple dynamic biological processes.Science advances · 2020Article
- Automated image analysis system for studying cardiotoxicity in human pluripotent stem cell-Derived cardiomyocytes.BMC bioinformatics · 2020Article
- Long-term single-cell passaging of human iPSC fully supports pluripotency and high-efficient trilineage differentiation capacity.SAGE open medicine · 2020Article
- Human induced pluripotent stem cells as a tool for disease modeling and drug screening for COVID-19.Genetics and molecular biology · 2020Article
- PSCRIdb: A database of regulatory interactions and networks of pluripotent stem cell lines.Journal of biosciences · 2020Article
- Genetic Ancestry Analysis Reveals Misclassification of Commonly Used Cancer Cell Lines.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Article
- Origin and age of the causative mutations in KLC2, IMPA1, MED25 and WNT7A unravelled through Brazilian admixed populations.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human pluripotent stem cells (hPSCs) may significantly improve drug development pipeline, serving as an in vitro system for the identification of novel leads, and for testing drug toxicity. Furthermore, these cells may be used to address the issue of differential drug response, a phenomenon greatly influenced by genetic factors. This application depends on the availability of hPSC lines from populations with diverse ancestries. So far, it has been reported that most lines of hPSCs derived worldwide are of European or East Asian ancestries. We have established 23 lines of hPSCs from Brazilian individuals, and we report the analysis of their genomic ancestry. We show that embryo-derived PSCs are mostly of European descent, while induced PSCs derived from participants of a national-wide Brazilian cohort study present high levels of admixed European, African and Native American genomic ancestry. Additionally, we use high density SNP data and estimate local ancestries, particularly those of CYP genes loci. Such information will be of key importance when interpreting variation among cell lines with respect to cellular phenotypes of interest. The availability of genetically admixed lines of hPSCs will be of relevance when setting up future in vitro studies of drug response.
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