ArticleScientific reports2016
Biotransformation of ferulic acid to vanillin in the packed bed-stirred fermentors.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 66 citations in OpenAlex.
- Vanillin Beyond Flavor: Therapeutic Potentials and Emerging Applications in Hydrogel-Based Biomaterials.Gels (Basel, Switzerland) · 2025Review
- A comprehensive review on microbial production of vanillin: metabolic engineering strategies and pathway-specific yields across microbial hosts.Archives of microbiology · 2025Review
- A comprehensive review of eclectic approaches to the biological synthesis of vanillin and their application towards the food sector.Food science and biotechnology · 2024Review
- Article
- Advances in engineeredSynthetic and systems biotechnology · 2021Review
- Antifungal Activity againstPlants (Basel, Switzerland) · 2021Article
- An integrative approach to improving the biocatalytic reactions of whole cells expressing recombinant enzymes.World journal of microbiology & biotechnology · 2021Review
- Mechanochemical Preparation of Magnetically Separable Fe and Cu-Based Bimetallic Nanocatalysts for Vanillin Production.Nanomaterials (Basel, Switzerland) · 2021Article
- Nano-Magnetic NiFeNanomaterials (Basel, Switzerland) · 2021Article
- One-Pot Cu/TiOMolecules (Basel, Switzerland) · 2019Article
- Genomic analysis ofBiotechnology for biofuels · 2019Article
- Comparative Studies of White-Rot Fungal Strains (ACS omega · 2018Article
- Molecular cloning and characterization of vanillin dehydrogenase from Streptomyces sp. NL15-2K.BMC microbiology · 2018Article
- Expression and characterization of a 9-cis-epoxycarotenoid dioxygenase fromBiotechnology reports (Amsterdam, Netherlands) · 2018Article
- Optimizing bioconversion of ferulic acid to vanillin byFood science and biotechnology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We performed the biotransformation of ferulic acid to vanillin using Bacillus subtilis (B. subtilis) in the stirring packed-bed reactors filled with carbon fiber textiles (CFT). Scanning electron microscope (SEM), HPLC, qRT-PCR and ATP assay indicated that vanillin biotransformation is tightly related to cell growth, cellar activity and the extent of biofilm formation. The biotransformation was affected by hydraulic retention time (HRT), temperature, initial pH, stirring speed and ferulic acid concentration, and the maximum vanillin production was obtained at 20 h, 35 °C, 9.0, 200 rpm, 1.5 g/L, respectively. Repeated batch biotransformation performed under this optimized condition showed that the maximum productivity (0.047 g/L/h) and molar yield (60.43%) achieved in immobilized cell system were 1.84 and 3.61 folds higher than those achieved in free cell system. Therefore, the stirring reactor packed with CFT carrier biofilm formed by B. subtilis represented a valid biocatalytic system for the production of vanillin.
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