Evidence map›Paper›PMID 27708348›Full record

ArticleScientific reports2016

A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP1

Jairo Andres Fonseca, Monica Cabrera-Mora, Balwan Singh, Joseli Oliveira-Ferreira, Josué da Costa Lima-Junior, J Mauricio Calvo-Calle, Jose Manuel Lozano, Alberto Moreno

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

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  4. A multivalentBioengineering & translational medicine · 2023
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  6. Frontiers in immunology · 2022
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  7. Frontiers in cellular and infection microbiology · 2022
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  8. Article
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  10. Review
  11. Progress towards the development of aExpert review of vaccines · 2021
    Review
  12. Protective Immunity in Mice Immunized WithFrontiers in immunology · 2020
    Article
  13. Article
  14. A Multi-StageFrontiers in cellular and infection microbiology · 2019
    Article
  15. Article
  16. Article
  17. Evaluation of a Major Surface Antigen ofFrontiers in microbiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Jairo Andres FonsecaEmory Vaccine Center, YerkesNational Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA.
Monica Cabrera-MoraEmory Vaccine Center, YerkesNational Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA.
Balwan SinghEmory Vaccine Center, YerkesNational Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA.
Joseli Oliveira-FerreiraLaboratory of Immunoparasitology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, (FIOCRUZ), Rio de Janeiro, RJ, Brazil.
Josué da Costa Lima-JuniorLaboratory of Immunoparasitology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, (FIOCRUZ), Rio de Janeiro, RJ, Brazil.
J Mauricio Calvo-CalleDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.
Jose Manuel LozanoMolecular Mimetism of Infectious Agents Unit, Department of Pharmacy, Universidad Nacional de Colombia, Bogota, Colombia.
Alberto MorenoEmory Vaccine Center, YerkesNational Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA.
Emory University · USFundação Oswaldo Cruz · BRUniversidad Nacional de Colombia · COUniversity of Massachusetts Chan Medical School · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
YNPRC NHP CLINICAL MEDICINE RESIDENCY PROGRAM - SUPPLEMENTP51RR000165 · NCRR · EMORY UNIVERSITY · PI ALTMAN, JOHN DAVID · 1985 to 2011
$114.0M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0M
T cell and transgenic core U19AI109858 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HUSEBY, ERIC S · 2014 to 2018
$11.9M
Optimization of chimeric multi-stage immunogens for malaria vaccine developmentR56AI103382 · NIAID · EMORY UNIVERSITY · PI MORENO, ALBERTO · 2014 to 2014
$844k
Coadministration of capsid modified adenovirus for malaria vaccine developmentR21AI095718 · NIAID · EMORY UNIVERSITY · PI MORENO, ALBERTO · 2012 to 2013
$490k
Novel DC targeted adenovirus vector for malaria vaccine developmentR21AI117459 · NIAID · EMORY UNIVERSITY · PI MORENO, ALBERTO · 2016 to 2017
$486k
Chimeric hybrid transmission blocking vaccine for malariaR21AI094402 · NIAID · EMORY UNIVERSITY · PI MORENO, ALBERTO · 2012 to 2013
$484k
NCRR NIH HHS P51 RR000165NIAID NIH HHS P30 AI050409NIAID NIH HHS R21 AI094402NIAID NIH HHS R21 AI095718NIAID NIH HHS R21 AI117459NIAID NIH HHS R56 AI103382NIAID NIH HHS U19 AI109858NIH HHS P51 OD011132
6 · The paper itself

Abstract

The most widespread Plasmodium species, Plasmodium vivax, poses a significant public health threat. An effective vaccine is needed to reduce global malaria burden. Of the erythrocytic stage vaccine candidates, the 19 kDa fragment of the P. vivax Merozoite Surface Protein 1 (PvMSP1

Indexed as

AnimalsCD8-Positive T-LymphocytesEpitopesFemaleMalaria VaccinesMalaria, VivaxMerozoite Surface Protein 1MiceMice, Inbred BALB CPlasmodium vivaxRecombinant Fusion ProteinsT-Lymphocytes, Helper-InducerEpitopesMalaria VaccinesMerozoite Surface Protein 1Recombinant Fusion Proteins

Identifiers

PMID27708348
PMCPMC5052570
OpenAlexW2528854515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.