ArticleNature communications2016
Evolutionary trajectories of snake genes and genomes revealed by comparative analyses of five-pacer viper.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 112 citations in OpenAlex.
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- Molecular mechanisms underlying early functional divergence in snake venom inferred from the genomes of two pitviper lineages.BMC biology · 2025Article
- Development of molecular markers for marker-assisted breeding and quality evaluation of Aconitum carmichaelii cultivars.BMC plant biology · 2025Article
- The Application of Microsatellite Markers as Molecular Tools for Studying Genomic Variability in Vertebrate Populations.Current issues in molecular biology · 2025Review
- Genomic insights and the conservation potential of captive breeding: The case of Chinese alligator.Science advances · 2025Article
- The proteotranscriptomic characterization of venom in the white seafanOpen biology · 2025Article
- Sex Chromosome Turnovers and Stability in Snakes.Molecular biology and evolution · 2025Article
- Where the "ruber" Meets the Road: Using the Genome of the Red Diamond Rattlesnake to Unravel the Evolutionary Processes Driving Venom Evolution.Genome biology and evolution · 2024Article
- Dynamic evolutionary interplay between ontogenetic skull patterning and whole-head integration.Nature ecology & evolution · 2024Article
- ToxCodAn-Genome: an automated pipeline for toxin-gene annotation in genome assembly of venomous lineages.GigaScience · 2024Article
- The genome assembly and annotation of the white-lipped tree pit viperGigaByte (Hong Kong, China) · 2024Article
- A genome assembly for the southern Pacific rattlesnake, Crotalus oreganus helleri, in the western rattlesnake species complex.The Journal of heredity · 2023Article
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- Genomic, transcriptomic, and epigenomic analysis of a medicinal snake,Acta pharmaceutica Sinica. B · 2023Article
- Origin and chromatin remodeling of young X/Y sex chromosomes in catfish with sexual plasticity.National science review · 2023Article
- Genomic investigation of the Chinese alligator reveals wild-extinct genetic diversity and genomic consequences of their continuous decline.Molecular ecology resources · 2023Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Snakes have numerous features distinctive from other tetrapods and a rich history of genome evolution that is still obscure. Here, we report the high-quality genome of the five-pacer viper, Deinagkistrodon acutus, and comparative analyses with other representative snake and lizard genomes. We map the evolutionary trajectories of transposable elements (TEs), developmental genes and sex chromosomes onto the snake phylogeny. TEs exhibit dynamic lineage-specific expansion, and many viper TEs show brain-specific gene expression along with their nearby genes. We detect signatures of adaptive evolution in olfactory, venom and thermal-sensing genes and also functional degeneration of genes associated with vision and hearing. Lineage-specific relaxation of functional constraints on respective Hox and Tbx limb-patterning genes supports fossil evidence for a successive loss of forelimbs then hindlimbs during snake evolution. Finally, we infer that the ZW sex chromosome pair had undergone at least three recombination suppression events in the ancestor of advanced snakes. These results altogether forge a framework for our deep understanding into snakes' history of molecular evolution.
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