ReviewNature reviews. Cardiology2017
The fractal heart - embracing mathematics in the cardiology clinic.
Review in Nature reviews. Cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Fractal dimension of the aortic annulus: a novel predictor of paravalvular leak after transcatheter aortic valve implantation.The international journal of cardiovascular imaging · 2022Trial
- Spatially heterogeneous ionic remodelling promotes wavefront instability in simulated atrial tissue.Frontiers in network physiology · 2026Article
- If things were simple, word would have gotten around. Can complexity science help us improve pediatric research?Pediatric research · 2025Review
- IsJournal of developmental biology · 2025Review
- Left ventricular trabecular complexity for risk stratification of cancer therapy-related cardiac dysfunction in breast cancer.MedComm · 2025Article
- Fractal analysis of left ventricular trabeculae in post-STEMI: from acute to chronic phase.Insights into imaging · 2024Article
- Box-Counting Fractal Analysis: A Primer for the Clinician.Advances in neurobiology · 2024Article
- Prognostic value of left ventricular trabeculae fractal analysis in patients with dilated cardiomyopathy.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024Article
- The application value of 24 h Holter monitoring indices in predicting MACEs outside the hospital within three years after PCI in patients with STEMI.Frontiers in cardiovascular medicine · 2024Article
- Multifractal foundations of biomarker discovery for heart disease and stroke.Scientific reports · 2023Article
- Quantitative Image Processing for Three-Dimensional Episcopic Images of Biological Structures: Current State and Future Directions.Biomedicines · 2023Review
- Excessive Trabeculation of the Left Ventricle: JACC: Cardiovascular Imaging Expert Panel Paper.JACC. Cardiovascular imaging · 2023Review
- Detection of Atrial Fibrillation Episodes based on 3D Algebraic Relationships between Cardiac Intervals.Diagnostics (Basel, Switzerland) · 2022Article
- Monofractal analysis of functional magnetic resonance imaging: An introductory review.Human brain mapping · 2022Review
- Reply to Stöllberger et al.Journal of anatomy · 2022Article
- Decrements in Adolescent Cardiac Complexity During Mother-Adolescent Conflicts.Applied psychophysiology and biofeedback · 2021Article
- Application of a Diagnostic Methodology of Cardiac Systems Based on the Proportions of Entropy in Normal Patients and with Different Pathologies.Pulse (Basel, Switzerland) · 2021Article
- Multi-Chaotic Analysis of Inter-Beat (R-R) Intervals in Cardiac Signals for Discrimination between Normal and Pathological Classes.Entropy (Basel, Switzerland) · 2021Article
- Fractal properties in sensorimotor variability unveil internal adaptations of the organism before symptomatic functional decline.Scientific reports · 2019Article
- Increased fractal dimension of left ventricular trabeculations is associated with subclinical diastolic dysfunction in patients with type-2 diabetes mellitus.The international journal of cardiovascular imaging · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
For clinicians grappling with quantifying the complex spatial and temporal patterns of cardiac structure and function (such as myocardial trabeculae, coronary microvascular anatomy, tissue perfusion, myocyte histology, electrical conduction, heart rate, and blood-pressure variability), fractal analysis is a powerful, but still underused, mathematical tool. In this Perspectives article, we explain some fundamental principles of fractal geometry and place it in a familiar medical setting. We summarize studies in the cardiovascular sciences in which fractal methods have successfully been used to investigate disease mechanisms, and suggest potential future clinical roles in cardiac imaging and time series measurements. We believe that clinical researchers can deploy innovative fractal solutions to common cardiac problems that might ultimately translate into advancements for patient care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.