ArticleThe American journal of tropical medicine and hygiene2016
Epidemiology and Control of Plasmodium vivax in Afghanistan.
Article in The American journal of tropical medicine and hygiene, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Use of malaria rapid diagnostic tests by community health workers in Afghanistan: cluster randomised trial.BMC medicine · 2017Trial
- Article
- Bridging the Gap from Molecular Surveillance to Programmatic Decisions for Malaria Control and Elimination.The American journal of tropical medicine and hygiene · 2025Review
- Malaria in Austria : A retrospective analysis of malaria cases diagnosed at a reference center in 2010-2020.Wiener klinische Wochenschrift · 2023Article
- Genetic diversity ofEpidemiology and infection · 2023Article
- Malaria in Afghanistan: Challenges, efforts and recommendations.Annals of medicine and surgery (2012) · 2022Article
- Case Report: Diagnostic Challenges in the Detection of a MixedThe American journal of tropical medicine and hygiene · 2020Article
- Clinical-Pathological Conference Series from the Medical University of Graz : Case No 174: A 25-year-old pregnant woman from Afghanistan with headache and a blast flag in the automated differential blood count.Wiener klinische Wochenschrift · 2020Article
- Chloroquine-Primaquine versus Chloroquine Alone to Treat Vivax Malaria in Afghanistan: An Open Randomized Superiority Trial.The American journal of tropical medicine and hygiene · 2017Article
- Cost-effectiveness of adding indoor residual spraying to case management in Afghan refugee settlements in Northwest Pakistan during a prolonged malaria epidemic.PLoS neglected tropical diseases · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Around half of the population of Afghanistan resides in areas at risk of malaria transmission. Two species of malaria (Plasmodium vivax and Plasmodium falciparum) account for a high burden of disease-in 2011, there were more than 300,000 confirmed cases. Around 80-95% of malaria is P. vivax Transmission is seasonal and focal, below 2,000 m in altitude, and in irrigated areas which allow breeding of anopheline mosquito vectors. Malaria risk is stratified to improve targeting of interventions. Sixty-three of 400 districts account for ∼85% of cases, and are the target of more intense control efforts. Pressure on the disease is maintained through case management, surveillance, and use of long-lasting insecticide-treated nets. Plasmodium vivax treatment is hampered by the inability to safely treat latent hypnozoites with primaquine because G6PD deficiency affects up to 10% of males in some ethnic groups. The risk of vivax malaria recurrence (which may be as a result of reinfection or relapse) is around 30-45% in groups not treated with primaquine but 3-20% in those given 14-day or 8-week courses of primaquine. Greater access to G6PD testing and radical treatment would reduce the number of incident cases, reduce the infectious reservoir in the population, and has the potential to reduce transmission as a result. Alongside the lack of G6PD testing, under-resourcing and poor security hamper the control of malaria. Recent gains in reducing the burden of disease are fragile and at risk of reversal if pressure on the disease is not maintained.
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