ArticleScience translational medicine2016
Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation.
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Article in Science translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
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Who cites it
40 citing papers in PubMed, 56 citations in OpenAlex.
- Dysregulated tissue immunity in human fatal asthma.Nature communications · 2026Article
- Mapping airway smooth muscle remodellingERJ open research · 2026Article
- HuR Regulates GATA3-Driven Type 2 Inflammation in CD4bioRxiv : the preprint server for biology · 2026Article
- Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma.Mucosal immunology · 2026Article
- A Quantitative Lung Mucin Score to Identify Chronic Bronchitis.NEJM evidence · 2026Article
- Airway epithelial heterogeneity and mucus plugging in asthmatic bronchioles.American journal of respiratory and critical care medicine · 2026Article
- EGFR inhibitors suppress house dust mite allergen Der pII induced inflammation in monocytes and macrophages.Frontiers in allergy · 2026Article
- The immunology of asthma.Nature immunology · 2025Review
- Tissue-Resident Th2 Cells in Type 2 Immunity and Allergic Diseases.Immunological reviews · 2025Review
- Innate Immunity and Asthma Exacerbations: Insights From Human Models.Immunological reviews · 2025Review
- Impact of Viral Lower Respiratory Tract Infection (LRTI) in Early Childhood (0-2 Years) on Lung Growth and Development and Lifelong Trajectories of Pulmonary Health: A National Institutes of Health (NIH) Workshop Summary.Pediatric pulmonology · 2025Review
- Emerging cell and molecular targets for treating mucus hypersecretion in asthma.Allergology international : official journal of the Japanese Society of Allergology · 2024Review
- Identification of common genes of rhinovirus single/double‑stranded RNA‑induced asthma deterioration by bioinformatics analysis.Experimental and therapeutic medicine · 2024Article
- Quantitation of MUC5AC and MUC5B by Stable Isotope Labeling Mass Spectrometry.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Inflammatory and tolerogenic myeloid cells determine outcome following human allergen challenge.The Journal of experimental medicine · 2023Article
- Air-Liquid interface cultures to model drug delivery through the mucociliary epithelial barrier.Advanced drug delivery reviews · 2023Review
- T helper 2 cells in asthma.The Journal of experimental medicine · 2023Review
- A human model of asthma exacerbation reveals transcriptional programs and cell circuits specific to allergic asthma.Science immunology · 2023Article
- Therapeutic Potential of Controlled Delivery Systems in Asthma: Preclinical Development of Flavonoid-Based Treatments.Pharmaceutics · 2022Review
- Physiology and pathophysiology of human airway mucus.Physiological reviews · 2022Review
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Authors and funding
21 authors at 4 institutions in 1 country.
Josalyn L ChoCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Morris F LingCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
David C AdamsDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Lucas FaustinoCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Sabina A IslamCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Roshi AfsharCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Jason W GriffithCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Robert S HarrisDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Aylwin NgCenter for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Giorgia RadicioniMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Amina A FordMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Andre K HanCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Ramnik XavierCenter for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
William W KwokBenaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.
Richard BoucherMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
James J MoonCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Daniel L HamilosCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Mehmet KesimerMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Melissa J SuterDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Benjamin D MedoffCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Andrew D LusterCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. aluster@mgh.harvard.edu.
Harvard University · USUniversity of North Carolina at Chapel Hill · USBroad Institute · USVirginia Mason Medical Center · US
Funding
Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2MPilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI ANDREW D LUSTER · 1991 to 2026
$35.3MTetramer CoreU19AI095261 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VON ANDRIAN, ULRICH H · 2011 to 2015
$10.8MResearch Training in Pulmonary Immunology and Allergy at MGHT32HL116275 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI David C Christiani, ANDREW D LUSTER · 2013 to 2026
$8.6MChemokines and Th2 Cell Trafficking in AsthmaR37AI040618 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LUSTER, ANDREW D · 2008 to 2017
$4.0MIncreasing the diagnostic yield of low-risk bronchial biopsy in the evaluation ofR01CA167827 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BOUMA, BRETT E, SUTER, MELISSA J · 2013 to 2017
$2.7MThe role of mucin-protein interactions in the innate defense of the lungR01HL103940 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESIMER, MEHMET · 2010 to 2014
$1.8MAirway mucus/mucin composition and proteome in COPD: A SPIROMICS ancillary studyR01HL110906 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESIMER, MEHMET · 2011 to 2014
$1.4MTim3 is a novel regulator of dendritic cell-T cell interactions in influenzaK08AI113083 · NIAID · UNIVERSITY OF IOWA · PI CHO, JOSALYN L · 2014 to 2018
$959kModulation of chronic Th2 inflammation by the CCR8 receptor-ligand pathwayR56AI101348 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI ISLAM, SABINA A · 2014 to 2014
$424kNCATS NIH HHS UL1 TR001102NCI NIH HHS R01 CA167827NHLBI NIH HHS R01 HL103940NHLBI NIH HHS R01 HL110906NHLBI NIH HHS T32 HL116275NIAID NIH HHS K08 AI113083NIAID NIH HHS R37 AI040618NIAID NIH HHS R56 AI101348NIAID NIH HHS U19 AI095261NIDDK NIH HHS P30 DK043351
Abstract
Despite systemic sensitization, not all allergic individuals develop asthma symptoms upon airborne allergen exposure. Determination of the factors that lead to the asthma phenotype in allergic individuals could guide treatment and identify novel therapeutic targets. We used segmental allergen challenge of allergic asthmatics (AA) and allergic nonasthmatic controls (AC) to determine whether there are differences in the airway immune response or airway structural cells that could drive the development of asthma. Both groups developed prominent allergic airway inflammation in response to allergen. However, asthmatic subjects had markedly higher levels of innate type 2 receptors on allergen-specific CD4
Indexed as
AdultAllergensAsthmaCytokinesHumansHypersensitivityInflammationLungMucusMuscle, SmoothPhenotypeTh2 CellsAllergensCytokines
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.