ArticleScience translational medicine2016
Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo.
Article in Science translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed.
- Retardance2Retardance: unsupervised denoising for polarization-sensitive optical coherence tomography.Biomedical optics express · 2026Article
- Correction method and tissue simulation approach for system polarization mode dispersion in polarization-sensitive OCT.Biomedical optics express · 2026Article
- Unambiguous polarimetric reconstruction in single-input polarization-sensitive OCT via spectral polarization spreading.Biomedical optics express · 2026Article
- Mapping airway smooth muscle remodellingERJ open research · 2026Article
- Innate Immunity and Asthma Exacerbations: Insights From Human Models.Immunological reviews · 2025Review
- Beyond bronchial thermoplasty - where to now?EClinicalMedicine · 2025Review
- Absolute depth-resolved optic axis measurement with catheter-based polarization sensitive optical coherence tomography.Biomedical optics express · 2024Article
- Mueller matrix analysis of a biologically sourced engineered tissue construct as polarimetric phantom.Journal of biomedical optics · 2024Article
- PneumaOCT: Pneumatic optical coherence tomography endoscopy for targeted distortion-free imaging in tortuous and narrow internal lumens.Science advances · 2024Article
- Translating endobronchial optical coherence tomography to clinical practice.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Immunologic aspects of asthma: from molecular mechanisms to disease pathophysiology and clinical translation.Frontiers in immunology · 2024Review
- Article
- Approach to Clinical Trials for the Prevention of Pulmonary Fibrosis.Annals of the American Thoracic Society · 2023Article
- Single-input polarization-sensitive optical coherence tomography through a catheter.Biomedical optics express · 2023Article
- In vivo polarisation sensitive optical coherence tomography for fibrosis assessment in interstitial lung disease: a prospective, exploratory, observational study.BMJ open respiratory research · 2023Observational
- Visualization and Validation of The Microstructures in The Airway Wall in vivo Using Diffractive Optical Coherence Tomography.Academic radiology · 2022Article
- Polarization-Sensitive Endobronchial Optical Coherence Tomography for Microscopic Imaging of Fibrosis in Interstitial Lung Disease.American journal of respiratory and critical care medicine · 2022Article
- Direct Visualization and Quantitative Imaging of Small Airway Anatomy In Vivo Using Deep Learning Assisted Diffractive OCT.IEEE transactions on bio-medical engineering · 2022Article
- Advancing Lung Immunology Research: An Official American Thoracic Society Workshop Report.American journal of respiratory cell and molecular biology · 2022Article
- Polarization mode dispersion correction in endoscopic polarization-sensitive optical coherence tomography with incoherent polarization input states.Biomedical optics express · 2022Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
The inability to visualize airway smooth muscle (ASM) cells in vivo is a major obstacle in understanding their role in normal physiology and diseases. At present, there is no imaging modality available to assess ASM in vivo. Confocal endomicroscopy lacks the penetration depth and field of view, and conventional optical coherence tomography (OCT) does not have sufficient contrast to differentiate ASM from surrounding tissues. We have developed a birefringence microscopy platform that leverages the micro-organization of tissue to add further dimension to traditional OCT. We have used this technology to validate ASM measurements in ex vivo swine and canine studies, visualize and characterize volumetric representations of ASM in vivo, and quantify and predict ASM contractile force as a function of optical retardation. We provide in vivo images and volumetric assessments of ASM in living humans and document structural disease variations in subjects with mild asthma. The opportunity to link inflammatory responses to ASM responses and to link ASM responses to clinical responses and outcomes could lead to an increased understanding of diseases of the airway and, ultimately, to improved patient outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.