ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016
A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- The Lamellar Cells of Vertebrate Meissner and Pacinian Corpuscles: Development, Characterization, and Functions.Frontiers in neuroscience · 2022Pooled it
- Neuromechanobiology: Bridging Mechanobiology and Neuroscience Through Evidence and Open Questions.Cells · 2026Review
- BACE1 regulates sleep-wake cycle through both enzymatic and non-enzymatic actions.EMBO reports · 2026Article
- Whole-Gut Spatial Genomic Analysis Reveals Molecular Regionalization of the Differentiating Zebrafish Enteric Nervous System.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Article
- Lamellar Schwann cells in the Pacinian corpuscle potentiate vibration perception.Science advances · 2025Article
- Genetic tools that target mechanoreceptors produce reliable labeling of bladder afferents and altered mechanosensation.American journal of physiology. Renal physiology · 2025Article
- Emergence of a brainstem somatosensory tonotopic map for substrate vibration.Nature neuroscience · 2025Article
- A Transcription Factor Etv1/Er81 Is Involved in the Differentiation of Sweet, Umami, and Sodium Taste Cells.eNeuro · 2023Article
- The interplay of common genetic variants NRG1 rs2439302 and RET rs2435357 increases the risk of developing Hirschsprung's disease.Frontiers in cell and developmental biology · 2023Article
- The structure of sensory afferent compartments in health and disease.Journal of anatomy · 2022Review
- The Etv1/Er81 transcription factor coordinates myelination-related genes to regulate Schwann cell differentiation and myelination.Annals of translational medicine · 2022Article
- Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adultScience advances · 2022Article
- Review
- USH2A is a Meissner's corpuscle protein necessary for normal vibration sensing in mice and humans.Nature neuroscience · 2021Article
- Insights Into the Role and Potential of Schwann Cells for Peripheral Nerve Repair From Studies of Development and Injury.Frontiers in molecular neuroscience · 2020Article
- Tiling and somatotopic alignment of mammalian low-threshold mechanoreceptors.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Feature-selective encoding of substrate vibrations in the forelimb somatosensory cortex.Nature · 2019Article
- A Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds.Cell reports · 2019Article
- Roof Plate-Derived Radial Glial-like Cells Support Developmental Growth of Rapidly Adapting Mechanoreceptor Ascending Axons.Cell reports · 2018Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 4 countries.
Funding
Abstract
Axon-Schwann cell interactions are crucial for the development, function, and repair of the peripheral nervous system, but mechanisms underlying communication between axons and nonmyelinating Schwann cells are unclear. Here, we show that ER81 is functionally required in a subset of mouse RET SIGNIFICANCE STATEMENT: Communication between neurons and Schwann cells is critical for development, normal function, and regeneration of the peripheral nervous system. Despite many studies about axonal communication with myelinating Schwann cells, mostly via a specific isoform of Neuregulin1, the molecular nature of axonal communication with nonmyelinating Schwann cells is poorly understood. Here, we described a RET-ER81-Neuregulin1 signaling pathway in neurons innervating Pacinian corpuscle somatosensory end organs, which is essential for communication between the innervating axon and the end organ nonmyelinating Schwann cells. We also showed that this signaling pathway uses isoforms of Neuregulin1 that are not involved in myelination, providing evidence that neurons use different isoforms of Neuregulin1 to interact with different types of Schwann cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.