ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016
Neuregulin-Dependent Regulation of Fast-Spiking Interneuron Excitability Controls the Timing of the Critical Period.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Pooled it
- Investigating hierarchical critical periods in human neurodevelopment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Tuning excitatory input to fast-spiking parvalbumin-positive interneurons: a lever for plasticity and hyperexcitability across the lifespan.Frontiers in synaptic neuroscience · 2026Article
- Cross-species evidence for the refinement of intrinsic neural timescales supporting executive system maturation through adolescence.bioRxiv : the preprint server for biology · 2025Article
- The Richness of Vision in the Mammalian Brain: Neural Codes for Visual Perception and Behavior in Three Dimensions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Connectivity, Computation, and Plasticity of the Early Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Recent Advances in the Molecular Mechanisms of Ocular Dominance Plasticity in the Visual Cortex.Neuroscience bulletin · 2025Review
- Comparative Neuroplasticity in Frontal- and Lateral-Eyed Mammals With Induced-Binocular Vision Dysfunction: Insights From Monocular Deprivation Models.The European journal of neuroscience · 2025Review
- ErbB inhibition rescues nigral dopamine neuron hyperactivity and repetitive behaviors in a mouse model of fragile X syndrome.Molecular psychiatry · 2025Article
- The Influence of Changes in Microglia Development on the Plasticity of the Developing Visual Cortex Circuit in Juvenile Mice.Investigative ophthalmology & visual science · 2025Article
- Fast-spiking parvalbumin-positive interneurons: new perspectives of treatment and future challenges in dementia.Molecular psychiatry · 2025Review
- In vivo whole-cortex marker of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- In-vivo whole-cortex marker of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth.bioRxiv : the preprint server for biology · 2024Article
- The neurochemistry of learning-driven sensory eye dominance plasticity.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Selective plasticity of fast and slow excitatory synapses on somatostatin interneurons in adult visual cortex.Nature communications · 2023Article
- Developmental loss of ErbB4 in PV interneurons disrupts state-dependent cortical circuit dynamics.Molecular psychiatry · 2023Article
- Amplified cortical neural responses as animals learn to use novel activity patterns.Current biology : CB · 2023Article
- ER-PM Junctions on GABAergic Interneurons Are Organized by Neuregulin 2/VAP Interactions and Regulated by NMDA Receptors.International journal of molecular sciences · 2023Article
- Psychedelics and Neural Plasticity: Therapeutic Implications.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Developmental, neurochemical, and behavioral analyses of ErbB4 Cyt-1 knockout mice.Journal of neurochemistry · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Maturation of excitatory drive onto fast-spiking interneurons (FS INs) in the visual cortex has been implicated in the control of the timing of the critical period for ocular dominance plasticity. However, the mechanisms that regulate the strength of these synapses over cortical development are not understood. Here we use a mouse model to show that neuregulin (NRG) and the receptor tyrosine kinase erbB4 regulate the timing of the critical period. NRG1 enhanced the strength of excitatory synapses onto FS INs, which inhibited ocular dominance plasticity during the critical period but rescued plasticity in transgenics with hypoexcitable FS INs. Blocking the effects of endogenous neuregulin via inhibition of erbBs rescued ocular dominance plasticity in postcritical period adults, allowing recovery from amblyopia induced by chronic monocular deprivation. Thus, the strength of excitation onto FS INs is a key determinant of critical period plasticity and is maintained at high levels by NRG-erbB4 signaling to constrain plasticity in adulthood. SIGNIFICANCE STATEMENT: Despite decades of experimentation, the mechanisms by which critical periods of enhanced synaptic plasticity are initiated and terminated are not completely understood. Here we show that neuregulin (NRG) and the receptor tyrosine kinase erbB4 determine critical period timing by controlling the strength of excitatory synapses onto FS INs. NRG1 enhanced excitatory drive onto fast spiking interneurons, which inhibited ocular dominance plasticity in juveniles but rescued plasticity in transgenics with hypoexcitable FS INs. Blocking the effects of endogenous neuregulin via inhibition of erbBs rescued ocular dominance plasticity in adults, allowing recovery from amblyopia induced by chronic monocular deprivation. Thus, in contrast to prevailing views of the termination of the critical period, active maintenance of strong excitation onto FS INs constrains plasticity in adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.