ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016
Basal Ganglia Output Controls Active Avoidance Behavior.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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Who cites it
38 citing papers in PubMed, 93 citations in OpenAlex.
- Histamine HMolecular psychiatry · 2026Article
- Medial prefrontal cortex encodes but is not required to generate goal-directed actions under threat.eLife · 2026Article
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- Medial prefrontal cortex encodes but is not required to generate goal-directed actions under threat.bioRxiv : the preprint server for biology · 2026Article
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- Behavioral outputs and overlapping circuits between conditional fear and active avoidance.Neurobiology of learning and memory · 2024Review
- Prefrontal control of superior colliculus modulates innate escape behavior following adversity.Nature communications · 2024Article
- Article
- Substantia Nigra Pars Reticulata Projections to the Pedunculopontine Nucleus Modulate Dyskinesia.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Pathway-specific inputs to the superior colliculus support flexible responses to visual threat.Science advances · 2023Article
- The Orienting Reflex Reveals Behavioral States Set by Demanding Contexts: Role of the Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Kappa Opioid Receptors Reduce Serotonin Uptake and Escitalopram Efficacy in the Mouse Substantia Nigra Pars Reticulata.International journal of molecular sciences · 2023Article
- The cortico-striatal circuitry in autism-spectrum disorders: a balancing act.Frontiers in cellular neuroscience · 2023Review
- A Voxel-Based Morphometric Study of Gray Matter in Specific Phobia.Life (Basel, Switzerland) · 2022Article
- Tripartite extended amygdala-basal ganglia CRH circuit drives locomotor activation and avoidance behavior.Science advances · 2022Article
- Augmented anandamide signalling in the substantia nigra pars reticulata mediates panicolytic-like effects in mice confronted by Crotalus durissus terrificus pit vipers.Psychopharmacology · 2022Article
- Caution Influences Avoidance and Approach Behaviors Differently.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Mitochondrial dysfunction and oxidative stress contribute to cognitive and motor impairment in FOXP1 syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A Signaled Locomotor Avoidance Action Is Fully Represented in the Neural Activity of the Midbrain Tegmentum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Engrained avoidance behavior is highly adaptive when it keeps away harmful events and can be highly maladaptive when individuals elude harmless situations in anxiety disorders, but the neural circuits that mediate avoidance are poorly understood. Using DREADDs and optogenetics in mice, we show that the output of the basal ganglia through the substantia nigra pars reticulata (SNr) controls active avoidance. SNr excitation blocks avoidance to a conditioned sensory stimulus while preserving the ability to escape the harmful event. Conversely, SNr inhibition facilitates avoidance to the conditioned stimulus and suffices to drive avoidance without any conditioned sensory stimulus. The results highlight a midbrain circuit that gates avoidance responses, which can be targeted to ameliorate maladaptive avoidance in psychiatric disorders. SIGNIFICANCE STATEMENT: In many circumstances, subjects respond to fearful situations with avoidance. This is a useful coping strategy in situations in which there is impending danger. However, avoidance responses can also be maladaptive, as in anxiety disorders such as phobias (e.g., avoiding air transportation) and social anxiety (e.g., avoiding social situations). Despite the obvious clinical relevance, little is known about the neural circuits that mediate active avoidance. Using chemogenetics and optogenetics, we show that the output of the basal ganglia fully controls active avoidance behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.