ArticleInternational journal of epidemiology2016
High-resolution metabolomics of occupational exposure to trichloroethylene.
Article in International journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Metabolomics for exposure assessment and toxicity effects of occupational pollutants: current status and future perspectives.Metabolomics : Official journal of the Metabolomic Society · 2022Pooled it
- 'Omics in environmental epidemiological studies of chemical exposures: A systematic evidence map.Environment international · 2022Pooled it
- Particulate metal exposures induce plasma metabolome changes in a commuter panel study.PloS one · 2018Trial
- Impact of multilingualism on cardiac autonomic activity, working memory and trait anxiety: a pilot study.Cognitive processing · 2026Article
- Predicting toxicity and bioactivity of the chemical exposome: a case study for the blood exposome database.Journal of cheminformatics · 2026Article
- Harnessing phytochemicals for engineering health solutions.Human genomics · 2026Review
- Exposure to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine under hypoxic conditions (%OToxicology letters · 2025Article
- Predicting Toxicity and Bioactivity of the Chemical Exposome: A Case Study for the Blood Exposome Database.bioRxiv : the preprint server for biology · 2025Article
- Integrating exposomics into biomedicine.Science (New York, N.Y.) · 2025Article
- Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues.Human genomics · 2025Review
- Trichloroethylene: An Update on an Environmental Contaminant with Multiple Health Effects.Annual review of pharmacology and toxicology · 2025Review
- Effects of exposure to trihalomethanes in swimming pool waters on metabolomics profile: a randomized parallel design trial.Journal of environmental health science & engineering · 2024Article
- Metabolomics and proteomics in occupational medicine: a comprehensive systematic review.Journal of occupational medicine and toxicology (London, England) · 2024Review
- Gene-environment interactions within a precision environmental health framework.Cell genomics · 2024Review
- Article
- Associations between metals and metabolomic profiles related to diabetes among adults in a rural region.Environmental research · 2024Article
- Dioxin(-like)-Related Biological Effects through Integrated Chemical-wide and Metabolome-wide Analyses.Environmental science & technology · 2024Article
- Exposome epidemiology for suspect environmental chemical exposures during pregnancy linked to subsequent breast cancer diagnosis.Environment international · 2023Article
- A global view of the genetic basis of Alzheimer disease.Nature reviews. Neurology · 2023Review
- Associations between residential volatile organic compound exposures and liver injury markers: The role of biological sex and race.Environmental research · 2023Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 7 institutions in 3 countries.
Funding
Abstract
backgroundOccupational exposure to trichloroethylene (TCE) has been linked to adverse health outcomes including non-Hodgkin's lymphoma and kidney and liver cancer; however, TCE's mode of action for development of these diseases in humans is not well understood.
methodsNon-targeted metabolomics analysis of plasma obtained from 80 TCE-exposed workers [full shift exposure range of 0.4 to 230 parts-per-million of air (ppm
resultsMetabolic features associated with TCE exposure included known TCE metabolites, unidentifiable chlorinated compounds and endogenous metabolites. Exposure resulted in a systemic response in endogenous metabolism, including disruption in purine catabolism and decreases in sulphur amino acid and bile acid biosynthesis pathways. Metabolite associations with TCE exposure included uric acid (β = 0.13, P-value = 3.6 × 10
conclusionsHigh-resolution metabolomics correlates measured occupational exposure to internal dose and metabolic response, providing insight into molecular mechanisms of exposure-related disease aetiology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.