ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2016
Developmental plasticity of mitochondrial function in American alligators, Alligator mississippiensis.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Cardiac mitochondria function in embryonic and 1-year old American alligators, Alligator mississippiensis, is not altered by hypoxic incubation or an acute anoxic challenge.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Article
- Developmental plasticity of the cardiovascular system in oviparous vertebrates: effects of chronic hypoxia and interactive stressors in the context of climate change.The Journal of experimental biology · 2024Review
- The Influence of Movement on the Cerebrospinal Fluid Pressure of the American Alligator (Biology · 2022Article
- Experimental demonstration of prenatal programming of mitochondrial aerobic metabolism lasting until adulthood.Proceedings. Biological sciences · 2022Article
- Developing chicken cardiac muscle mitochondria are resistant to variations in incubation oxygen levels.Current research in physiology · 2022Article
- Prenatal acoustic programming of mitochondrial function for high temperatures in an arid-adapted bird.Proceedings. Biological sciences · 2021Article
- Changes in hemoglobin function and isoform expression during embryonic development in the American alligator,American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- The Long-Term Effects of Developmental Hypoxia on Cardiac Mitochondrial Function in Snapping Turtles.Frontiers in physiology · 2021Article
- Growing up gator: a proteomic perspective on cardiac maturation in an oviparous reptile, the American alligator (Alligator mississippiensis).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Hypoxia-induced reprogramming of the cardiac phenotype in American alligators (Alligator mississippiensis) revealed by quantitative proteomics.Scientific reports · 2019Article
- The effects of embryonic hypoxic programming on cardiovascular function and autonomic regulation in the American alligator (Alligator mississippiensis) at rest and during swimming.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2018Article
- Suppression of reactive oxygen species generation in heart mitochondria from anoxic turtles: the role of complex IThe Journal of experimental biology · 2018Article
- Evolved changes in the intracellular distribution and physiology of muscle mitochondria in high-altitude native deer mice.The Journal of physiology · 2017Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The effect of hypoxia on cellular metabolism is well documented in adult vertebrates, but information is entirely lacking for embryonic organisms. The effect of hypoxia on embryonic physiology is particularly interesting, as metabolic responses during development may have life-long consequences, due to developmental plasticity. To this end, we investigated the effects of chronic developmental hypoxia on cardiac mitochondrial function in embryonic and juvenile American alligators (Alligator mississippiensis). Alligator eggs were incubated in 21% or 10% oxygen from 20 to 90% of embryonic development. Embryos were either harvested at 90% development or allowed to hatch and then reared in 21% oxygen for 3 yr. Ventricular mitochondria were isolated from embryonic/juvenile alligator hearts. Mitochondrial respiration and enzymatic activities of electron transport chain complexes were measured with a microrespirometer and spectrophotometer, respectively. Developmental hypoxia induced growth restriction and increased relative heart mass, and this phenotype persisted into juvenile life. Embryonic mitochondrial function was not affected by developmental hypoxia, but at the juvenile life stage, animals from hypoxic incubations had lower levels of Leak respiration and higher respiratory control ratios, which is indicative of enhanced mitochondrial efficiency. Our results suggest developmental hypoxia can have life-long consequences for alligator morphology and metabolic function. Further investigations are necessary to reveal the adaptive significance of the enhanced mitochondrial efficiency in the hypoxic phenotype.
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