ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2017
Preeclampsia and ESRD: The Role of Shared Risk Factors.
Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- A systematic review on the determinants of long-term kidney sequelae after hypertensive diseases of pregnancy.Acta obstetricia et gynecologica Scandinavica · 2025Pooled it
- Chronic kidney disease, female infertility, and medically assisted reproduction: a best practice position statement by the Kidney and Pregnancy Group of the Italian Society of Nephrology.Journal of nephrology · 2023Guideline
- Adverse Pregnancy Outcomes and Long-term Maternal Kidney Disease: A Systematic Review and Meta-analysis.JAMA network open · 2020Pooled it
- Divergent Risk Factors and Outcomes in Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome and Isolated Preeclampsia.Kidney international reports · 2026Article
- Identification of a DICER1 mutation in a preeclamptic patient with ruptured ovarian Sertoli-Leydig cell tumor and renal allograft failure under hemodialysis: a case report.BMC pregnancy and childbirth · 2026Article
- Blood Pressure Thresholds for Hypertension in Pregnancy and Future Cardiovascular Risk.Mayo Clinic proceedings · 2025Article
- Kidney health outcomes of hypertensive disorders of pregnancy.Nature reviews. Nephrology · 2025Review
- Hypertensive Disorders of Pregnancy: Reaching the Rural Population After Delivery.Current hypertension reports · 2025Review
- Recurrence of preeclampsia is common, even during rigorously controlled multidisciplinary follow-up: a pilot experience.Clinical kidney journal · 2025Article
- The ABCs of post-preeclampsia outpatient nephrology care: the Le Mans strategy.Journal of nephrology · 2024Article
- Discover overlooked complications after preeclampsia from three real-world medical record datasets of over 100,000 pregnancies.medRxiv : the preprint server for health sciences · 2024Article
- A Study on Associations of Long Noncoding RNA HOTAIR Polymorphisms With Genetic Susceptibility to Chronic Kidney Disease.Journal of clinical laboratory analysis · 2024Article
- Pre-gestational counselling for women living with CKD: starting from the bright side.Clinical kidney journal · 2024Review
- Discover overlooked complications after preeclampsia using electronic health records.Research square · 2024Article
- Management of Pregnancy in Persons with Kidney Failure Treated with Hemodialysis.Clinical journal of the American Society of Nephrology : CJASN · 2023Article
- VASCULAR AND RENAL MECHANISMS OF PREECLAMPSIA.Current opinion in physiology · 2023Article
- Article
- Kidney Biopsy in Pregnant Women with Glomerular Diseases: Focus on Lupus Nephritis.Journal of clinical medicine · 2023Review
- Adding creatinine to routine pregnancy tests: a decision tree for calculating the cost of identifying patients with CKD in pregnancy.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Article
- What a paediatric nephrologist should know about preeclampsia and why it matters.Pediatric nephrology (Berlin, Germany) · 2022Review
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundSeveral registry-based studies, using diagnostic codes, have suggested that preeclampsia is a risk factor for end-stage renal disease (ESRD). However, because the 2 diseases share risk factors, the true nature of their association remains uncertain. Our goals were to conduct a population-based study to determine the magnitude of the association between preeclampsia and ESRD and evaluate the role of shared risk factors. STUDY
designPopulation-based nested case-control study. SETTING &
participantsThe US Renal Data System was used to identify women with ESRD from a cohort of 34,581 women who gave birth in 1976 to 2010 in Olmsted County, MN. 44 cases of ESRD were identified and each one was matched to 2 controls based on year of birth (±1 year), age at first pregnancy (±2 years), and parity (±1 or ≥4). PREDICTOR: Preeclamptic pregnancy, confirmed by medical record review. OUTCOME: ESRD. MEASUREMENTS: Prepregnancy serum creatinine and urine protein measurements were recorded. Comorbid conditions existing prior to pregnancy were abstracted from medical records and included kidney disease, obesity, diabetes, and hypertension.
resultsThere was evidence of kidney disease prior to the first pregnancy in 9 of 44 (21%) cases and 1 of 88 (<1%) controls. Per chart review, 8 of 44 (18%) cases versus 4 of 88 (5%) controls had preeclamptic pregnancies (unadjusted OR, 4.0; 95% CI, 1.21-13.28). Results were similar after independent adjustment for race, education, diabetes, and hypertension prior to pregnancy. However, the association was attenuated and no longer significant after adjustment for obesity (OR, 3.25; 95% CI, 0.93-11.37). LIMITATIONS: The limited number of ESRD cases and missing data for prepregnancy kidney function.
conclusionsOur findings confirm that there is a sizable association between preeclampsia and ESRD; however, obesity is a previously unexplored confounder. Pre-existing kidney disease was common, but not consistently coded or diagnosed.
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