Evidence map›Paper›PMID 27707500›Full record

ReviewLancet (London, England)2016

Pathophysiology, research challenges, and clinical management of smoke inhalation injury.

Perenlei Enkhbaatar, Basil A Pruitt, Oscar Suman, Ronald Mlcak, Steven E Wolf, Hiroyuki Sakurai, David N Herndon

Registry-linked trialAbstract readReview
In one paragraph

Review in Lancet (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07520071 (Assessment of Changes in Range of Motion and Muscle Endurance After Practicing the "Xuong Tan Lac Than" Exercise in Healthy Volunteers), which is not on this map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07520071 narecruitingnot on this mapstarted 2026, after this paper: background citation

Assessment of Changes in Range of Motion and Muscle Endurance After Practicing the "Xuong Tan Lac Than" Exercise in Healthy Volunteers

TypeinterventionalSponsorUniversity of Medicine and Pharmacy at Ho Chi Minh CityRan2026 to 2026Enrolled34ConditionsHealthy, Physical FitnessArms"Xuong tan lac than" exercise
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Safety of Nebulized Epinephrine in Smoke Inhalation Injury.Journal of burn care & research : official publication of the American Burn Association
    Trial
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Critical Care of the Pediatric Burn Patient.Seminars in plastic surgery · 2024
    Review
  16. Article
  17. Protection of laryngeal mucosa and function in laryngeal burns by heat absorption of perilaryngeal tissue.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Article
  18. Artificial porphyrin molecules clean up carbon monoxide and cyanide.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. A synthetic porphyrin as an effective dual antidote against carbon monoxide and cyanide poisoning.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Perenlei EnkhbaatarDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: peenkhba@utmb.edu.
Basil A PruittDepartment of Surgery, Division of Trauma, University of Texas Health Science Center, San Antonio, TX, USA.
Oscar SumanDepartment of Surgery, University of Texas Medical Branch, Galveston, TX, USA; Shriners Hospitals for Children, Galveston, TX, USA.
Ronald MlcakShriners Hospitals for Children, Galveston, TX, USA; Department of Respiratory Care, School of Health Professions, University of Texas Medical Branch, Galveston, TX, USA.
Steven E WolfDepartment of Surgery, University of Texas, Southwestern Medical Center, Dallas, TX, USA.
Hiroyuki SakuraiDepartment of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Tokyo, Japan.
David N HerndonDepartment of Surgery, University of Texas Medical Branch, Galveston, TX, USA; Shriners Hospitals for Children, Galveston, TX, USA.

Funding

UTMB Clinical and Translational Science AwardUL1TR001439 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI URBAN, RANDALL J · 2015 to 2024
$40.0M
Project 9: The role of androgen/corticosteroid in fat, muscle and glucose metabolism of burn victimsP50GM060338 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI SZABO, CSABA · 2000 to 2017
$24.2M
MODULATION OF THE POSTBURN HYPERMETABOLIC RESPONSER01GM056687 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI HERNDON, DAVID N. · 1998 to 2017
$9.0M
Oxandrolone and Exercise: A potent therapy in the rehabilitation from burnsR01HD049471 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SUMAN-VEJAS, OSCAR E. · 2006 to 2019
$5.8M
POSTDOCTORAL TRAINING IN TRAUMA &BURNST32GM008256 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI Celeste Campbell Finnerty, Oscar E. Suman-Vejas · 1990 to 2026
$4.0M
NCATS NIH HHS UL1 TR001439NICHD NIH HHS R01 HD049471NIGMS NIH HHS P50 GM060338NIGMS NIH HHS R01 GM056687NIGMS NIH HHS T32 GM008256
6 · The paper itself

Abstract

Smoke inhalation injury is a serious medical problem that increases morbidity and mortality after severe burns. However, relatively little attention has been paid to this devastating condition, and the bulk of research is limited to preclinical basic science studies. Moreover, no worldwide consensus criteria exist for its diagnosis, severity grading, and prognosis. Therapeutic approaches are highly variable depending on the country and burn centre or hospital. In this Series paper, we discuss understanding of the pathophysiology of smoke inhalation injury, the best evidence-based treatments, and challenges and future directions in diagnostics and management.

Indexed as

BurnsHumansPrognosisResearchSmoke Inhalation Injury

Identifiers

PMID27707500
PMCPMC5241273

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.