ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2016
Swimming training attenuates oxidative damage and increases enzymatic but not non-enzymatic antioxidant defenses in the rat brain.
Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Effects of moderate- and high-intensity exercise on behavior and oxidative damage in male and female rats subjected to early life stress.Experimental brain research · 2026Article
- Protective effect and molecular mechanisms of magnolol in ischemic stroke.Pharmacological reports : PR · 2025Review
- Swimming Training Prevents Stress-Induced Spatial Memory Impairment by Reducing Neurodegenerative Changes in Hippocampus.Biochemistry research international · 2025Article
- Protective effect of fisetin against subchronic chlorpyrifos-induced toxicity on oxidative stress biomarkers and neurobehavioral parameters in adult male albino mice.Toxicological research · 2021Article
- Multiple Applications of Different Exercise Modalities with Rodents.Oxidative medicine and cellular longevity · 2021Review
- The role of exercise in brain DNA damage.Neural regeneration research · 2020Review
- Psychobiotic Effects of Multi-Strain Probiotics Originated from Thai Fermented Foods in a Rat Model.Food science of animal resources · 2020Article
- The Effect of Swimming on Anxiety-Like Behaviors and Corticosterone in Stressed and Unstressed Rats.International journal of environmental research and public health · 2020Article
- Role of neuronal nitric oxide synthase on cardiovascular functions in physiological and pathophysiological states.Nitric oxide : biology and chemistry · 2020Review
- Prior exercise protects against oxidative stress and motor deficit in a rat model of Parkinson's disease.Metabolic brain disease · 2020Article
- Assessment of Serum Cytokines and Oxidative Stress Markers in Elite Athletes Reveals Unique Profiles Associated With Different Sport Disciplines.Frontiers in physiology · 2020Article
- Effect of photobiomodulation therapy on oxidative stress markers of gastrocnemius muscle of diabetic rats subjected to high-intensity exercise.Lasers in medical science · 2018Article
- Photobiomodulation Leads to Reduced Oxidative Stress in Rats Submitted to High-Intensity Resistive Exercise.Oxidative medicine and cellular longevity · 2018Article
- Alterations of the oxidative status in rat hippocampus and prodepressant effect of chronic testosterone enanthate administration.Molecular and cellular biochemistry · 2017Article
- Photobiomodulation therapy associated with treadmill training in the oxidative stress in a collagen-induced arthritis model.Lasers in medical science · 2017Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although it is well known that physical training ameliorates brain oxidative function after injuries by enhancing the levels of neurotrophic factors and oxidative status, there is little evidence addressing the influence of exercise training itself on brain oxidative damage and data is conflicting. This study investigated the effect of well-established swimming training protocol on lipid peroxidation and components of antioxidant system in the rat brain. Male Wistar rats were randomized into trained (5 days/week, 8 weeks, 30 min; n=8) and non-trained (n=7) groups. Forty-eight hours after the last session of exercise, animals were euthanized and the brain was collected for oxidative stress analysis. Swimming training decreased thiobarbituric acid reactive substances (TBARS) levels (P<0.05) and increased the activity of the antioxidant enzyme superoxide dismutase (SOD) (P<0.05) with no effect on brain non-enzymatic total antioxidant capacity, estimated by FRAP (ferric-reducing antioxidant power) assay (P>0.05). Moreover, the swimming training promoted metabolic adaptations, such as increased maximal workload capacity (P<0.05) and maintenance of body weight. In this context, the reduced TBARS content and increased SOD antioxidant activity induced by 8 weeks of swimming training are key factors in promoting brain resistance. In conclusion, swimming training attenuated oxidative damage and increased enzymatic antioxidant but not non-enzymatic status in the rat brain.
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