ArticlePloS one2016
Molecular Typing of Legionella pneumophila Isolates in the Province of Quebec from 2005 to 2015.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Clinical, laboratory, and radiological features of community-acquired pneumonia due toAnnals of medicine · 2026Article
- Unravelling the Genomic and Virulence Diversity ofMicroorganisms · 2025Article
- Expanded geographic distribution for twomSphere · 2024Article
- Evaluation of Genetic Diversity and Virulence Potential ofPathogens (Basel, Switzerland) · 2023Article
- Prevalence and Genetic Diversity ofMicroorganisms · 2023Article
- Detection of Diverse Sequence Types of Legionella pneumophila by Legiolert Enzymatic-Based Assay and the Development of a Long-Term Storage Protocol.Microbiology spectrum · 2022Article
- Presence of Viable, Clinically RelevantMicrobiology spectrum · 2022Article
- Bacterial Antagonistic Species of the Pathogenic GenusMicroorganisms · 2022Article
- Article
- Local Adaptation of Legionella pneumophila within a Hospital Hot Water System Increases Tolerance to Copper.Applied and environmental microbiology · 2021Article
- How Molecular Typing Can SupportInternational journal of environmental research and public health · 2020Article
- Identification of two aptamers binding to Legionella pneumophila with high affinity and specificity.Scientific reports · 2020Article
- A Snapshot of the Prevalence and Molecular Diversity ofPathogens (Basel, Switzerland) · 2020Article
- Fatal Case of Nosocomial Legionella pneumophila Pneumonia, Spain, 2018.Emerging infectious diseases · 2019Article
- Genomic heterogeneity differentiates clinical and environmental subgroups of Legionella pneumophila sequence type 1.PloS one · 2018Article
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7 authors.
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Abstract
Legionella is found in natural and man-made aquatic environments, such as cooling towers and hot water plumbing infrastructures. Legionella pneumophila serogroup 1 (Lp1) is the most common etiological agent causing waterborne disease in the United States and Canada. This study reports the molecular characterization of Lp strains during a 10 year period. We conducted sequence-based typing (SBT) analysis on a large set of Lp isolates (n = 284) to investigate the province of Quebec sequence types (STs) distribution in order to identify dominant clusters. From 2005 to 2015, 181 clinical Lp isolates were typed by SBT (141 sporadic cases and 40 outbreak related cases). From the same period of time, 103 environmental isolates were also typed. Amongst the 108 sporadic cases of Lp1 typed, ST-62 was the most frequent (16.6%), followed by ST-213 (10.2%), ST-1 (8.3%) and ST-37 (8.3%). Amongst other serogroups (SG), ST-1327 (SG5) (27.3%) and ST-378 (SG10) (12.2%) were the most frequent. From the environmental isolates, ST-1 represent the more frequent SBT type (26.5%). Unweighted pair group method with arithmetic mean (UPGMA) dendrogram from the 108 sporadic cases of SG1 contains 4 major clusters (A to D) of related STs. Cluster B contains the majority of the strains (n = 61) and the three most frequent STs in our database (ST-62, ST-213 and ST-1). During the study period, we observed an important increase in the incidence rate in Quebec. All the community associated outbreaks, potentially or confirmed to be associated with a cooling tower were caused by Lp1 strains, by opposition to hospital associated outbreaks that were caused by serogroups of Lp other than SG1. The recent major Quebec City outbreak caused by ST-62, and the fact that this genotype is the most common in the province supports whole genome sequencing characterization of this particular sequence type in order to understand its evolution and associated virulence factors.
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