Evidence map›Paper›PMID 27706158›Full record

ArticlePLoS neglected tropical diseases2016

Colorimetric Detection of Plasmodium vivax in Urine Using MSP10 Oligonucleotides and Gold Nanoparticles.

Yossef Alnasser, Cusi Ferradas, Taryn Clark, Maritza Calderon, Alejandro Gurbillon, Dionicia Gamboa, Uri S McKakpo, Isabella A Quakyi, Kwabena M Bosompem, David J Sullivan and 2 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Rapid Detection ofFrontiers in cellular and infection microbiology · 2022
    Article
  3. Biosensor Based Immunoassay: A New Approach for Serotyping ofNanomaterials (Basel, Switzerland) · 2021
    Article
  4. Article
  5. Colorimetric-based detection ofIET nanobiotechnology · 2020
    Article
  6. An Update on Malaria Rapid Diagnostic Tests.Current infectious disease reports · 2018
    Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Yossef AlnasserJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
Cusi FerradasUniversidad Peruana Cayetano Heredia, Lima, Peru.
Taryn ClarkUniversidad Peruana Cayetano Heredia, Lima, Peru.
Maritza CalderonUniversidad Peruana Cayetano Heredia, Lima, Peru.
Alejandro GurbillonUniversidad Peruana Cayetano Heredia, Lima, Peru.
Dionicia GamboaUniversidad Peruana Cayetano Heredia, Lima, Peru.
Uri S McKakpoSchool of Public Health and Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana.
Isabella A QuakyiSchool of Public Health and Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana.
Kwabena M BosompemSchool of Public Health and Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana.
David J SullivanJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
Joseph M VinetzUniversidad Peruana Cayetano Heredia, Lima, Peru.
Robert H GilmanJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
Universidad Peruana Cayetano Heredia · PEJohns Hopkins University · USNoguchi Memorial Institute for Medical Research · GHKing Saud University · SAUniversity of California, San Diego · USUniversity of Ghana · GH

Funding

Sugar-feeding behavior of the malaria vector Nyssorhynchus darlingi and development of effective attractive toxic sugar baits (ATSB) to increase intervention success in PeruU19AI089681 · NIAID · YALE UNIVERSITY · PI GAZZINELLI, RICARDO TOSTES · 2010 to 2023
$20.1M
Vector Biology Research and Integrated Vector Management For Malaria ControlU19AI089702 · NIAID · CAUCASECO SCIENTIFIC RESEARCH CENTER · PI HERRERA VALENCIA, SOCRATES · 2010 to 2016
$11.5M
Medical Research Council MR/K007467/1NIAID NIH HHS U19 AI089681NIAID NIH HHS U19 AI089702
6 · The paper itself

Abstract

Plasmodium vivax is the most prevalent cause of human malaria in the world and can lead to severe disease with high potential for relapse. Its genetic and geographic diversities make it challenging to control. P. vivax is understudied and to achieve control of malaria in endemic areas, a rapid, accurate, and simple diagnostic tool is necessary. In this pilot study, we found that a colorimetric system using AuNPs and MSP10 DNA detection in urine can provide fast, easy, and inexpensive identification of P. vivax. The test exhibited promising sensitivity (84%), high specificity (97%), and only mild cross-reactivity with P. falciparum (21%). It is simple to use, with a visible color change that negates the need for a spectrometer, making it suitable for use in austere conditions. Using urine eliminates the need for finger-prick, increasing both the safety profile and patient acceptance of this model.

Indexed as

Metal NanoparticlesOligonucleotidesAntigens, ProtozoanColorimetryCross ReactionsDNA, ProtozoanGoldHumansMalaria, VivaxMass ScreeningMicroscopyParasitemiaPilot ProjectsPlasmodium vivaxProtozoan ProteinsSensitivity and SpecificityAntigens, ProtozoanDNA, ProtozoanGoldOligonucleotidesProtozoan Proteins

Identifiers

PMID27706158
PMCPMC5051960
OpenAlexW2527836177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.