ArticlePloS one2016
Influenza Pandemics and Tuberculosis Mortality in 1889 and 1918: Analysis of Historical Data from Switzerland.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Influenza and tuberculosis co-infection: A systematic review.Influenza and other respiratory viruses · 2020Pooled it
- Drivers of Seasonal Variation in Tuberculosis Incidence: Insights from a Systematic Review and Mathematical Model.Epidemiology (Cambridge, Mass.) · 2018Pooled it
- Review
- Influenza coinfection inhibits control of mycobacterial infection in a human challenge model.Nature communications · 2026Article
- Tuberculosis Trends in the Post-COVID-19 Era: Is It Going to be a Global Concern?Health science reports · 2025Article
- SARS-CoV-2 coinfection in children with severe airway obstruction due to pulmonary tuberculosis.Pediatric pulmonology · 2024Article
- The health and demographic impacts of the "Russian flu" pandemic in Switzerland in 1889/1890 and in the years thereafter.Epidemiology and infection · 2024Article
- Changes in incidence and clinical features of tuberculosis with regard to the COVID-19 outbreak in Southern Iran.BMC infectious diseases · 2024Article
- An extended period of elevated influenza mortality risk follows the main waves of influenza pandemics.Social science & medicine (1982) · 2023Article
- The COVID-19 and TB syndemic: the way forward.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022Review
- Historically High Excess Mortality During the COVID-19 Pandemic in Switzerland, Sweden, and Spain.Annals of internal medicine · 2022Observational
- Epidemic and pandemic viral infections: impact on tuberculosis and the lung: A consensus by the World Association for Infectious Diseases and Immunological Disorders (WAidid), Global Tuberculosis Network (GTN), and members of the European Society of Clinical Microbiology and Infectious Diseases Study Group for Mycobacterial Infections (ESGMYC).The European respiratory journal · 2020Review
- Tuberculosis control and care in the era of COVID-19.Health policy and planning · 2020Article
- Assessment of Mental Health Factors among Health Professionals Depending on Their Contact with COVID-19 Patients.International journal of environmental research and public health · 2020Article
- Navigating COVID-19 in the developing world.Clinical rheumatology · 2020Article
- Tuberculosis as a Risk Factor for 1918 Influenza Pandemic Outcomes.Tropical medicine and infectious disease · 2019Article
- The Impact of Influenza and Tuberculosis Interaction on Mortality Among Individuals Aged ≥15 Years Hospitalized With Severe Respiratory Illness in South Africa, 2010-2016.Open forum infectious diseases · 2019Article
- Prevalence and clinical significance of respiratory viruses and bacteria detected in tuberculosis patients compared to household contact controls in Tanzania: a cohort study.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2019Article
- Influenza interaction with cocirculating pathogens and its impact on surveillance, pathogenesis, and epidemic profile: A key role for mathematical modelling.PLoS pathogens · 2018Review
- The convergent epidemiology of tuberculosis and human cytomegalovirus infection.F1000Research · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTuberculosis (TB) mortality declined in the northern hemisphere over the last 200 years, but peaked during the Russian (1889) and the Spanish (1918) influenza pandemics. We studied the impact of these two pandemics on TB mortality.
methodsWe retrieved historic data from mortality registers for the city of Bern and countrywide for Switzerland. We used Poisson regression models to quantify the excess pulmonary TB (PTB) mortality attributable to influenza.
resultsYearly PTB mortality rates increased during both influenza pandemics. Monthly influenza and PTB mortality rates peaked during winter and early spring. In Bern, for an increase of 100 influenza deaths (per 100,000 population) monthly PTB mortality rates increased by a factor of 1.5 (95%Cl 1.4-1.6, p<0.001) during the Russian, and 3.6 (95%Cl 0.7-18.0, p = 0.13) during the Spanish pandemic. Nationally, the factor was 2.0 (95%Cl 1.8-2.2, p<0.001) and 1.5 (95%Cl 1.1-1.9, p = 0.004), respectively. We did not observe any excess cancer or extrapulmonary TB mortality (as a negative control) during the influenza pandemics.
conclusionsWe demonstrate excess PTB mortality during historic influenza pandemics in Switzerland, which supports a role for influenza vaccination in PTB patients in high TB incidence countries.
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