Evidence map›Paper›PMID 27706049›Full record

ArticleToxins2016

Structural and Functional Elucidation of Peptide Ts11 Shows Evidence of a Novel Subfamily of Scorpion Venom Toxins.

Caroline M Cremonez, Mohitosh Maiti, Steve Peigneur, Juliana Silva Cassoli, Alexandre A A Dutra, Etienne Waelkens, Eveline Lescrinier, Piet Herdewijn, Maria Elena de Lima, Adriano M C Pimenta and 2 more

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. The First KToxins · 2025
    Article
  6. Understanding the complexity ofThe journal of venomous animals and toxins including tropical diseases · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Scorpion Venom-Toxins that Aid in Drug Development: A Review.International journal of peptide research and therapeutics · 2019
    Review
  16. Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression.The journal of venomous animals and toxins including tropical diseases · 2019
    Article
  17. Article
  18. Effects of Brazilian scorpion venoms on the central nervous system.The journal of venomous animals and toxins including tropical diseases · 2018
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Caroline M CremonezLaboratório de Toxinas Animais, Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto 14040-903, São Paulo, Brasil. carolmarroni@yahoo.com.br.
Mohitosh MaitiLaboratory for Medicinal Chemistry, Rega Institute for Medical Research, University of Leuven (KU Leuven), P.O. Box 922, Leuven 3000, Belgium. mohitosh_maiti@yahoo.com.
Steve PeigneurToxicology & Pharmacology, University of Leuven (KU Leuven), Campus Gasthuisberg O&N2, P.O. Box 922, Leuven 3000, Belgium. steve.peigneur@pharm.kuleuven.be.
Juliana Silva CassoliLaboratório de Venenos e Toxinas Animais, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte 31270-901, Brasil. jscassoli@gmail.com.
Alexandre A A DutraLaboratório de Venenos e Toxinas Animais, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte 31270-901, Brasil. aledutra@gmail.com.
Etienne WaelkensLaboratory of Protein Phosphorylation and Proteomics, University of Leuven (KU Leuven), P.O. Box 922, Leuven 3000, Belgium. etienne.waelkens@med.kuleuven.be.
Eveline LescrinierLaboratory for Medicinal Chemistry, Rega Institute for Medical Research, University of Leuven (KU Leuven), P.O. Box 922, Leuven 3000, Belgium. eveline.lescrinier@rega.kuleuven.be.
Piet HerdewijnLaboratory for Medicinal Chemistry, Rega Institute for Medical Research, University of Leuven (KU Leuven), P.O. Box 922, Leuven 3000, Belgium. piet.herdewijn@rega.kuleuven.be.
Maria Elena de LimaLaboratório de Venenos e Toxinas Animais, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte 31270-901, Brasil. melenalima@icb.ufmg.br.
Adriano M C PimentaLaboratório de Venenos e Toxinas Animais, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte 31270-901, Brasil. apimenta@icb.ufmg.br.
Eliane C ArantesLaboratório de Toxinas Animais, Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto 14040-903, São Paulo, Brasil. ecabraga@fcfrp.usp.br.
Jan TytgatToxicology & Pharmacology, University of Leuven (KU Leuven), Campus Gasthuisberg O&N2, P.O. Box 922, Leuven 3000, Belgium. jan.tytgat@pharm.kuleuven.be.
Universidade Federal de Minas Gerais · BRKU Leuven · BERega Institute for Medical Research · BEUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To date, several families of peptide toxins specifically interacting with ion channels in scorpion venom have been described. One of these families comprise peptide toxins (called KTxs), known to modulate potassium channels. Thus far, 202 KTxs have been reported, belonging to several subfamilies of KTxs (called α, β, γ, κ, δ, and λ-KTxs). Here we report on a previously described orphan toxin from

Indexed as

Amino Acid SequenceAnimalsArthropod ProteinsOocytesPeptidesPotassium Channels, Voltage-GatedScorpion VenomsToxins, BiologicalVoltage-Gated Sodium ChannelsXenopus laevisArthropod ProteinsPeptidesPotassium Channels, Voltage-GatedScorpion VenomsToxins, BiologicalVoltage-Gated Sodium ChannelselectrophysiologyICK foldneurotoxinNMRpotassium channelprotein structurescorpion toxinTityus serrulatusTs11

Identifiers

PMID27706049
PMCPMC5086648
OpenAlexW2525698946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.