Evidence map›Paper›PMID 27705789›Full record

ArticleCell reports2016

Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection.

Marcela Montes de Oca, Rajiv Kumar, Fabian de Labastida Rivera, Fiona H Amante, Meru Sheel, Rebecca J Faleiro, Patrick T Bunn, Shannon E Best, Lynette Beattie, Susanna S Ng and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 106 citations in OpenAlex.

  1. Trial
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  9. Regulatory T cell memory: implications for malaria.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Review
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 3 countries.

Marcela Montes de OcaQIMR Berghofer Medical Research Institute, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia; School of Medicine, University of Queensland, Brisbane, QLD 4072, Australia.
Rajiv KumarQIMR Berghofer Medical Research Institute, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia; Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India.
Fabian de Labastida RiveraQIMR Berghofer Medical Research Institute, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia.
Fiona H AmanteQIMR Berghofer Medical Research Institute, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia.
Meru SheelQIMR Berghofer Medical Research Institute, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia.
Rebecca J FaleiroQIMR Berghofer Medical Research Institute, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia.
Patrick T BunnQIMR Berghofer Medical Research Institute, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia; Institute of Glycomics, Griffith University, Gold Coast, Southport, QLD 4215, Australia.
Shannon E BestQIMR Berghofer Medical Research Institute, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia.
Lynette BeattieQIMR Berghofer Medical Research Institute, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia.
Susanna S NgQIMR Berghofer Medical Research Institute, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia; School of Natural Sciences, Griffith University, Nathan, QLD 4111, Australia.
Chelsea L EdwardsQIMR Berghofer Medical Research Institute, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia; School of Medicine, University of Queensland, Brisbane, QLD 4072, Australia.
Glen M BoyleQIMR Berghofer Medical Research Institute, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia.
Ric N PriceMenzies School of Health Research, Darwin, NT 0811, Australia; Charles Darwin University, Darwin, NT 0810, Australia; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7BN, UK.
Nicholas M AnsteyMenzies School of Health Research, Darwin, NT 0811, Australia; Charles Darwin University, Darwin, NT 0810, Australia.
Jessica R LoughlandMenzies School of Health Research, Darwin, NT 0811, Australia; Charles Darwin University, Darwin, NT 0810, Australia.
Julie BurelQIMR Berghofer Medical Research Institute, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia.
Denise L DoolanQIMR Berghofer Medical Research Institute, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia.
Ashraful HaqueQIMR Berghofer Medical Research Institute, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia.
James S McCarthyQIMR Berghofer Medical Research Institute, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia; School of Medicine, University of Queensland, Brisbane, QLD 4072, Australia. Electronic address: j.mccarthy@uq.edu.au.
Christian R EngwerdaQIMR Berghofer Medical Research Institute, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia. Electronic address: chrise@qimr.edu.au.
QIMR Berghofer Medical Research Institute · AURoyal Brisbane and Women's Hospital · AUGriffith University · AUCharles Darwin University · AUMenzies School of Health Research · AUUniversity of Oxford · GBUniversity of Queensland · AU

Funding

Wellcome Trust 091625
6 · The paper itself

Abstract

The development of immunoregulatory networks is important to prevent disease. However, these same networks allow pathogens to persist and reduce vaccine efficacy. Here, we identify type I interferons (IFNs) as important regulators in developing anti-parasitic immunity in healthy volunteers infected for the first time with Plasmodium falciparum. Type I IFNs suppressed innate immune cell function and parasitic-specific CD4

Indexed as

Antiparasitic AgentsCD4-Positive T-LymphocytesHealthy VolunteersHost-Parasite InteractionsHumansImmunity, InnateInterferon-gammaInterferon Type IInterleukin-10Malaria, FalciparumPlasmodium falciparumTh1 CellsAntiparasitic AgentsIFNG protein, humanInterferon-gammaInterferon Type IInterleukin-10CD4(+) T cellsimmune regulationmalariaTh1 cellsTr1 cellstype I interferons

Identifiers

PMID27705789
PMCPMC5082731
OpenAlexW2528369300

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.